The JAK/STAT3 signaling pathway mediates inhibition of host cell apoptosis by Chlamydia psittaci infection

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成果类型：

期刊论文、会议论文

作者：

Sun, Yuanbin;Zhou, Peng;Chen, Shenghua;Hu, Chunsheng;Bai, Qinqin;...

通讯作者：

Chen, Lili

作者机构：

[Bai, Qinqin; Zeng, Xindian; Chen, Lili; Zhou, Pufan; Liu, Ziqing; Zhou, Peng; Sun, Yuanbin] Univ South China, Coll Publ Hlth, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Chen, Shenghua] Univ South China, Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wu, Haiying] Univ South China, Affiliated Hosp 2, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Hu, Chunsheng] Hunan Prov Ctr Dis Control & Provent, Outpatient Dept, Changsha 421000, Hunan, Peoples R China.

[Chen, Yuyu] Cent S Univ, Hunan Canc Hosp, Changsha 421000, Hunan, Peoples R China.

通讯机构：

[Chen, Lili] U

Univ South China, Coll Publ Hlth, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Chlamydia psittaci;STAT3;apoptosis;Bax/Bcl-2

期刊：

Pathogens and Disease

ISSN：

0928-8244

年：

2017

卷：

期：

页码：

188-188

会议名称：

2017年第二届全国特殊病原体学术会议

会议论文集名称：

2017年第二届全国特殊病原体学术会议论文集

会议时间：

2017-08-13

会议地点：

南京

会议赞助商：

中华医学会

DOI：

10.1093/femspd/ftx088

基金类别：

This work was supported by the National Natural Science Foundation of China (grant no. 81572011, 31600150), the Natural Science Foundation of Hunan Province (2016JJ3103) and the Construct Program of the Key Discipline (Public Health and Preventive Medicine) in Hunan Province.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

The Janus kinase-signal transducer and activator of transcription-3 (JAK-STAT3) signaling pathway is a key regulator of cell growth, motility, migration, invasion and apoptosis in mammalian cells. Infection with intracellular pathogens of the genus Chlamydia can inhibit host cell apoptosis, and here we asked whether the JAK-STAT3 pathway participates in chlamydial anti-apoptotic activity. We found that, compared with uninfected cells, levels of JAK1 and STAT3 mRNA as well as total and phosphorylated JAK1 and STAT3 protein were significantly increased in Chlamydia psittaci-infected HeLa cells. ...

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The JAK/STAT3 signaling pathway mediates inhibition of host cell apoptosis by Chlamydia psittaci infection

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