Zinc (Zn(2+)) is an essential trace element that plays a crucial role in various biological functions. Aberrant Zn(2+) homeostasis may lead to the occurrence and development of diseases. Zinc transporters, primarily classified into two families in humans: the ZnT (SLC30A) family and the ZIP (SLC39A) family, are critical regulators of Zn(2+) homeostasis. The roles of ZnT-mediated Zn(2+) homeostasis in diseases are an active area of research. The ZnT family comprises ten members, belonging to four subfamilies, which are widely distributed in various tissues and subcellular organelles. ZnTs media...
