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Nanoscale Calculation of Proton-Induced DNA Damage Using a Chromatin Geometry Model with Geant4-DNA

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成果类型:
期刊论文
作者:
Zhu, Kun;Wu, Chun;Peng, Xiaoyu;Ji, Xuantao;Luo, Siyuan;...
通讯作者:
Xiaodong Wang
作者机构:
[Liu, Yuchen; Luo, Siyuan; Wang, Xiaodong; Ji, Xuantao; Zhu, Kun; Peng, Xiaoyu] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
[Wu, Chun] Univ South China, Sch Nursing, Hengyang 421001, Peoples R China.
通讯机构:
[Xiaodong Wang] S
School of Nuclear Science and Technology, University of South China, Hengyang 421001, China<&wdkj&>Author to whom correspondence should be addressed.
语种:
英文
关键词:
Monte Carlo simulation;Geant4-DNA;DNA damage;uncertainty analysis
期刊:
International Journal of Molecular Sciences
ISSN:
1422-0067
年:
2022
卷:
23
期:
11
页码:
6343-
基金类别:
Conceptualization, K.Z., X.W. and C.W.; methodology, K.Z. and Y.L.; software, K.Z.; validation, K.Z. and C.W.; formal analysis, K.Z.; investigation, S.L. and X.J.; resources, K.Z.; data curation, K.Z.; writing—original draft preparation, K.Z.; writing—review and editing, K.Z.; visualization, Y.L. and X.P.; supervision, X.W.; project administration, X.W.; funding acquisition, X.W. and C.W. All authors have read and agreed to the published version of the manuscript. This work was funded by the National Natural Science Foundation of China (11875163) and the Foundation of Education Bureau of Hunan Province (19C1590).
机构署名:
本校为第一机构
院系归属:
核科学技术学院
护理学院
摘要:
Monte Carlo simulations can quantify various types of DNA damage to evaluate the biological effects of ionizing radiation at the nanometer scale. This work presents a study simulating the DNA target response after proton irradiation. A chromatin fiber model and new physics constructors with the ELastic Scattering of Electrons and Positrons by neutral Atoms (ELSEPA) model were used to describe the DNA geometry and the physical stage of water radiolysis with the Geant4-DNA toolkit, respectively. Three key parameters (the energy threshold model for strand breaks, the physics model and the maximum...

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