Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling

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成果类型：

期刊论文

作者：

Yan, Limei;Hao, Hong;Elton, Terry S.;Liu, Zhenguo*;Ou, Hesheng

通讯作者：

Liu, Zhenguo

作者机构：

[Yan, Limei] Univ S China, Biochem Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Liu, Zhenguo; Hao, Hong; Elton, Terry S.; Ou, Hesheng] Ohio State Univ, Med Ctr, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.

[Liu, Zhenguo; Hao, Hong; Elton, Terry S.; Ou, Hesheng] Ohio State Univ, Med Ctr, Div Cardiovasc Med, Columbus, OH 43210 USA.

[Ou, Hesheng] Guangxi Med Univ, Coll Pharm, Nanning 530021, Peoples R China.

[Liu, Zhenguo] Ohio State Univ, Med Ctr, Davis Heart & Lung Res Inst, DHLRI Suite 200,473 W 12th Ave, Columbus, OH 43210 USA.

通讯机构：

[Liu, Zhenguo] O

Ohio State Univ, Med Ctr, Davis Heart & Lung Res Inst, DHLRI Suite 200,473 W 12th Ave, Columbus, OH 43210 USA.

语种：

英文

关键词：

microRNA;eNOS;STAT3;Intron;Repeat polymorphism;Endothelial cell proliferation

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2011

卷：

357

期：

1-2

页码：

9-19

DOI：

10.1007/s11010-011-0870-x

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30670834, 30871186]; Research Foundation of the Education Department of Hunan Province, China [06A060]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Intronic microRNA (miRNAs) suppressed the expression of endothelial nitric oxide synthase (eNOS) gene in endothelial cells (ECs). This study was to investigate the role of signal transducer and activator of transcription 3 (STAT3) in the regulation of eNOS expression and vascular EC proliferation by the intronic 27-nucleotide (nt) miRNA derived from the 27-base pair repeats in intron 4 of eNOS gene. A detectable level of the 27-nt miRNA was present in the control ECs. Overexpression of the 27-nt miRNA dramatically suppressed the expression of eNOS and STAT3 at both transcription and translatio...

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Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling

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