Screening and Identification of the Binding Peptides of Mycoplasma genitalium Protein of Adhesion

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Dai, Pei;Zhu, Youcong;You, Xiaoxing;Deng, Xiangying;Zhu, Cuiming;...

通讯作者：

Zeng, Yanhua

作者机构：

[Luo, Dan; Dai, Pei; Zhu, Youcong; Deng, Xiangying; Zhu, Cuiming; Chen, Liesong; You, Xiaoxing; Zeng, Yanhua; Li, Lingling] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, 28 West Changsheng Rd,Zhengxiang Dist St, Hengyang 421001, Hunan, Peoples R China.

[Luo, Dan; Dai, Pei; Zhu, Youcong; Deng, Xiangying; Zhu, Cuiming; Chen, Liesong; You, Xiaoxing; Zeng, Yanhua; Li, Lingling] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

[Zhu, Youcong] Yiyang Med Coll, Dept Surg Nursing, Yiyang 413000, Hunan, Peoples R China.

通讯机构：

[Zeng, Yanhua] U

[Zeng, Yanhua] H

Univ South China, Inst Pathogen Biol, Hengyang Med Coll, 28 West Changsheng Rd,Zhengxiang Dist St, Hengyang 421001, Hunan, Peoples R China.

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Mycoplasma genitalium;Adhesin protein;Phage display random peptide library;Binding peptides

期刊：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS

ISSN：

1573-3149

年：

2019

卷：

期：

页码：

1379-1388

DOI：

10.1007/s10989-018-9783-9

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31370207, 81871256]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Mycoplasma genitalium protein of adhesion (MgPa) is a vital membrane protein, which plays an important role in mediating the adhesion and infection of M. genitalium to host cells. This study aims to screen and identify the specific binding peptides of MgPa. Phage display with random 12-mer and 7-mer peptide libraries was carried out to obtain the phages specifically bound to recombinant MgPa (rMgPa). Two concensus core sequences, i.e. VHWDFRQWWQPS and DWSSWVH(Y)RDPQT(S), were identified from the 12-mer peptide library and one consistent core sequence, i.e. HYIDFRW, was obtained from the 7-mer ...

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Screening and Identification of the Binding Peptides of Mycoplasma genitalium Protein of Adhesion

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