Toll-like receptor protein 4 monoclonal antibody inhibits mmLDL-induced endothelium-dependent vasodilation dysfunction of mouse mesenteric arteries

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成果类型：

期刊论文

作者：

Chen, Gen;Chen, Xiao-Lan;Xu, Cang-Bao;Lin, Jie;Luo, Hong-Li;...

通讯作者：

Li, Jie

作者机构：

[Li, Jie; Chen, Gen; Xie, Xi] Univ South China, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Chen, Xiao-Lan; Li, Jie; Lin, Jie] Xiangnan Univ, Peoples Hosp Chenzhou 1, Chenzhou 423000, Hunan, Peoples R China.

[Xu, Cang-Bao] Xian Med Univ, Inst Basic & Translat Med, Shaanxi Key Lab Ischem Cardiovasc Dis, Xian, Shaanxi, Peoples R China.

[Luo, Hong-Li] Southwest Med Univ, Affiliated Hosp, Dept Pharm, Luzhou, Sichuan, Peoples R China.

通讯机构：

[Li, Jie] X

Xiangnan Univ, Peoples Hosp Chenzhou 1, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

Endothelium-dependent vasodilation;Inflammation;Mesenteric artery;TLR4 mAb;mmLDL

期刊：

Microvascular Research

ISSN：

0026-2862

年：

2020

卷：

127

页码：

103923

DOI：

10.1016/j.mvr.2019.103923

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81202535, 81470493]; Natural Science Fund Project of the Hunan Provincial Science and Technology Department [2018JJ6097]; Technology Research and Development Center of Chenzhou, the Science and Technology Bureau of Chenzhou, Hunan Province [zdyf201821]; Science and Technology Strategic Cooperation Project of Luzhou Municipal Peoples Government and Southwest Medical University, Sichuan Province, China [2016LZXNYD-J14]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Minimally modified low-density lipoprotein (mmLDL) is a risk factor for cardiovascular disease. This study was designed to investigate the effect of a Toll-like receptor 4 monoclonal antibody (TLR4 mAb) on mmLDL-induced endothelium-dependent vasodilation (EDV) impairment in mouse mesenteric arteries and to explore the underlying mechanism. Animals were divided into a normal control group, an mmLDL treatment group, and a TLR4 mAb intervention group. The serum concentrations of IL-1beta and TNF-alpha were detected using enzyme-linked immunosorbent assays (ELISAs). EDV function was measured using...

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Toll-like receptor protein 4 monoclonal antibody inhibits mmLDL-induced endothelium-dependent vasodilation dysfunction of mouse mesenteric arteries

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