Lentivirus-mediated over-expression of let-7b microRNA suppresses hepatic fibrosis in the mouse infected with Schistosoma japonicum

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Na;Wu, Yuan;Cao, Weiliang;Liang, Yu;Gao, Yongqiang;...

通讯作者：

Xiao, Jianhua;Tang, Faqing

作者机构：

[Liang, Yu; Xiao, Jianhua; Tang, Na; Gao, Yongqiang; Cao, Weiliang; Hu, Li] Univ South China, Inst Pathogen Biol, Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Yuqiu; Tang, Na] Zhuhai Maternal & Child Hlth Care Hosp, Dept Clin Lab, Zhuhai 519000, Guangdong, Peoples R China.

[Wu, Yuan] Univ South China, Affiliated Hosp 2, Hengyang 421001, Peoples R China.

[Yang, Qinglan] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Clin Lab, Sch Med, Shanghai 200030, Peoples R China.

[Tang, Faqing] Cent S Univ, Hunan Canc Hosp, Clin Lab, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Xiao, Jianhua] U

[Tang, Faqing] C

[Xiao, Jianhua] H

Univ South China, Inst Pathogen Biol, Med Coll, Hengyang 421001, Hunan, Peoples R China.

Cent S Univ, Hunan Canc Hosp, Clin Lab, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Let-7b miRNA;Schistosomiasis liver fibrosis (SLF);Suppress;TbetaRI

期刊：

Experimental Parasitology

ISSN：

0014-4894

年：

2017

卷：

182

页码：

45-53

DOI：

10.1016/j.exppara.2017.09.024

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30972576, 81101274]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [11JJ9022]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative innovation Center for Molecular Target New Drug Study [2015-8]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Transforming growth factor-β (TGF-β) signaling pathway is documented to participate in liver fibrosis via multifactorial mechanisms. microRNA Let-7b (Let-7b) has been proved to alleviate cell fibrosis through regulating TGF-β receptor I (TβRI), but whether it is involved in Schistosomiasis liver fibrosis (SLF) has not been determined. In the present, SLF mice model was used to investigate Let-7b's function and mechanism in SLF. We found that hepatic let-7b expression was continuously declined in SLF, accompanied by the induction of TGF-β p...

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Lentivirus-mediated over-expression of let-7b microRNA suppresses hepatic fibrosis in the mouse infected with Schistosoma japonicum

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