期刊论文

Effect of Erythropoietin on Inflammation of Cerebral Ischemia-reperfusion Injury in Rats

中文

中国康复理论与实践

1006-9771

2008

14

8

729-730

10.3969/j.issn.1006-9771.2008.08.012

本校为第一机构

目的 探讨促红细胞生成素(EPO)对大鼠局灶性脑缺血再灌注后炎症损伤的保护作用.方法 54只SD大鼠随机分为假手术组、生理盐水对照组、EPO治疗组,采用线栓法制备大鼠大脑中动脉阻塞2 h模型,再灌注6 h、24 h、48 h.放免法检测各时间点白细胞介素1β(IL-1β)含量.比色法观察髓过氧化物酶(MPO)活性,同时观察24 h时间点神经功能缺损评分.结果 EPO组大鼠各时间点脑组织中的IL-1β含量和MPO活性降低(P

Objective To explore the protective effect of erythropoietin（EPO）on inflammatory injury induced by focal cerebral ischemia/reperfusion in rats.Methods 54 male Sprague-Dawley rats were randomly divided into 3 groups：sham operation group,normal saline control group and EPO group.The focal cerebral ischemia-reperfusion injury model was made by suture-occluded method.The content of interleukin-1 β（IL-1β）and the activity of myeloperoxidease（MPO）were measured by radioimmunoassay and chromatoptometry at 6 h,24 h and 48 h reperfusion following...