期刊论文

Yu, C.-Y.

英文

Journal of Applied Polymer Science

1097-4628

2015

132

40

-

10.1002/app.42625

National Natural Science Foundation of China [81471777, 81102409]; Department of Science and Technology of Hunan Province [2014GK3082, 2012FJ2016]; Natural Science Foundation of Hunan province [13JJ6096]; Innovation Team of Antitumor Drugs [NHCXTD05]; Young Talent Program of the University of South China; Health Department of Hunan Province 225 Talent Project; Construct Program of the Key Discipline in Hunan Province

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In this study, a novel type of macromolecular prodrug, N-galactosylated chitosan (GC)-5-fluorouracil acetic acid (FUA) conjugate based nanoparticles, was designed and synthesized as a carrier for hepatocellular carcinoma drug delivery. The GC-FUA nanoparticles were produced by an ionic crosslinking method based on the modified ionic gelation of tripolyphosphate with GC-FUA. The structure of the as-prepared GC-FUA was characterized by Fourier transform infrared and H-1-NMR analyses. The average particle size of the GC-FUA nanoparticles was 160.1 nm, and their drug-loading content was 21.22 +/- 2.7% (n=3). In comparison with that of the freshly prepared nanoparticles, this value became larger after 7 days because of the aggregation of the GC-FUA nanoparticles. An in vitro drug-release study showed that the GC-FUA nanoparticles displayed a sustained-release profile compared to 5-fluorouracil-loaded GC nanoparticles. All of the results suggest that the GC-FUA nanoparticles may have great potential for anti-liver-cancer applications. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42625.