Fabrication of galactosylated chitosan-5-fluorouracil acetic acid based nanoparticles for controlled drug delivery

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成果类型：

期刊论文

作者：

Yu, Cui-Yun*;Li, Na-Mei;Yang, Sa;Ning, Qian;Huang, Can;...

通讯作者：

Yu, Cui-Yun

作者机构：

[He, Zi-Ning; Huang, Wen; Huang, Can; He, Dong-Xiu; Tan, Xiang-Wen; Li, Na-Mei; Sun, Li-Chun; Yang, Sa; Yu, Cui-Yun; Ning, Qian] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Yu, Cui-Yun] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Hengyang 421001, Peoples R China.

[Sun, Li-Chun] Tulane Univ, Dept Med, Hlth Sci Ctr, New Orleans, LA 70112 USA.

通讯机构：

[Yu, Cui-Yun] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

biomaterials;biomedical applications;drug-delivery systems;nanostructured polymers

期刊：

Journal of Applied Polymer Science

ISSN：

0021-8995

年：

2015

卷：

132

期：

页码：

DOI：

10.1002/app.42625

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471777, 81102409]; Department of Science and Technology of Hunan Province [2014GK3082, 2012FJ2016]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [13JJ6096]; Innovation Team of Antitumor Drugs [NHCXTD05]; Young Talent Program of the University of South China; Health Department of Hunan Province 225 Talent Project; Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

ABSTRACT In this study, a novel type of macromolecular prodrug, N‐galactosylated chitosan (GC)−5‐fluorouracil acetic acid (FUA) conjugate based nanoparticles, was designed and synthesized as a carrier for hepatocellular carcinoma drug delivery. The GC–FUA nanoparticles were produced by an ionic crosslinking method based on the modified ionic gelation of tripolyphosphate with GC–FUA. The structure of the as‐prepared GC–FUA was characterized by Fourier transform infrared and 1H‐NMR analyses. The average particle size of the GC–FUA nanopa...

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Fabrication of galactosylated chitosan-5-fluorouracil acetic acid based nanoparticles for controlled drug delivery

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