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Fabrication of galactosylated chitosan-5-fluorouracil acetic acid based nanoparticles for controlled drug delivery

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成果类型:
期刊论文
作者:
Yu, Cui-Yun;Li, Na-Mei;Yang, Sa;Ning, Qian;Huang, Can;Huang, Wen;He, Zi-Ning;He, Dong-Xiu;Tan, Xiang-Wen;Sun, Li-Chun
通讯作者:
Yu, C.-Y.
作者机构:
Hunan Province Cooperative Innovation Center for Molecular Target New Drug StudyUniversity of South ChinaHengyang421001 China<&wdkj&>Learning Key Laboratory for Pharmacoproteomics of Hunan ProvinceInstitute of Pharmacy and Pharmacology, University of South ChinaHengyang421001 China<&wdkj&>Department of MedicineTulane University Health Sciences CenterNew Orleans Louisiana70112
[Huang, Can; He, Zi-Ning; Li, Na-Mei; Ning, Qian; Sun, Li-Chun; Yu, Cui-Yun; Yang, Sa; Huang, Wen; Tan, Xiang-Wen; He, Dong-Xiu] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China
[Sun, Li-Chun] Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States
[Yu, Cui-Yun] Learning Key Laboratory for Pharmacoproteomics of Hunan Province, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China
通讯机构:
[Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
biomaterials;biomedical applications;drug‐delivery systems;nanostructured polymers
期刊:
Journal of Applied Polymer Science
ISSN:
1097-4628
年:
2015
卷:
132
期:
40
页码:
-
基金类别:
National Natural Science Foundation of China [81471777, 81102409]; Department of Science and Technology of Hunan Province [2014GK3082, 2012FJ2016]; Natural Science Foundation of Hunan province [13JJ6096]; Innovation Team of Antitumor Drugs [NHCXTD05]; Young Talent Program of the University of South China; Health Department of Hunan Province 225 Talent Project; Construct Program of the Key Discipline in Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
In this study, a novel type of macromolecular prodrug, N-galactosylated chitosan (GC)-5-fluorouracil acetic acid (FUA) conjugate based nanoparticles, was designed and synthesized as a carrier for hepatocellular carcinoma drug delivery. The GC-FUA nanoparticles were produced by an ionic crosslinking method based on the modified ionic gelation of tripolyphosphate with GC-FUA. The structure of the as-prepared GC-FUA was characterized by Fourier transform infrared and H-1-NMR analyses. The average particle size of the GC-FUA nanoparticles was 160.1 nm, and their drug-loading content was 21.22 +/- 2.7% (n=3). In comparison with that of the freshly prepared nanoparticles, this value became larger after 7 days because of the aggregation of the GC-FUA nanoparticles. An in vitro drug-release study showed that the GC-FUA nanoparticles displayed a sustained-release profile compared to 5-fluorouracil-loaded GC nanoparticles. All of the results suggest that the GC-FUA nanoparticles may have great potential for anti-liver-cancer applications. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42625.

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