Fabrication of galactosylated chitosan-5-fluorouracil acetic acid based nanoparticles for controlled drug delivery

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成果类型：

期刊论文

作者：

Yu, Cui-Yun*;Li, Na-Mei;Yang, Sa;Ning, Qian;Huang, Can;...

通讯作者：

Yu, Cui-Yun

作者机构：

[He, Zi-Ning; Huang, Wen; Huang, Can; He, Dong-Xiu; Tan, Xiang-Wen; Li, Na-Mei; Sun, Li-Chun; Yang, Sa; Yu, Cui-Yun; Ning, Qian] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Yu, Cui-Yun] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Hengyang 421001, Peoples R China.

[Sun, Li-Chun] Tulane Univ, Dept Med, Hlth Sci Ctr, New Orleans, LA 70112 USA.

通讯机构：

[Yu, Cui-Yun] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Acetic acid;Biomaterials;Chitosan;Crosslinking;Drug products;Functional polymers;Gelation;Medical applications;Nanoparticles;Particle size;Particle size analysis;pH;Synthesis (chemical);Targeted drug delivery;Average particle size;Biomedical applications;Drug delivery system;Fourier transform infra reds;Galactosylated chitosan;Hepatocellular carcinoma;Ionic crosslinking;Nanostructured polymers;Controlled drug delivery

期刊：

Journal of Applied Polymer Science

ISSN：

0021-8995

年：

2015

卷：

132

期：

页码：

DOI：

10.1002/app.42625

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471777, 81102409]; Department of Science and Technology of Hunan Province [2014GK3082, 2012FJ2016]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [13JJ6096]; Innovation Team of Antitumor Drugs [NHCXTD05]; Young Talent Program of the University of South China; Health Department of Hunan Province 225 Talent Project; Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

In this study, a novel type of macromolecular prodrug, N-galactosylated chitosan (GC)-5-fluorouracil acetic acid (FUA) conjugate based nanoparticles, was designed and synthesized as a carrier for hepatocellular carcinoma drug delivery. The GC-FUA nanoparticles were produced by an ionic crosslinking method based on the modified ionic gelation of tripolyphosphate with GC-FUA. The structure of the as-prepared GC-FUA was characterized by Fourier transform infrared and 1H-NMR analyses. The average particle size of the GC-FUA nanoparticles was 160.1 ...

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Fabrication of galactosylated chitosan-5-fluorouracil acetic acid based nanoparticles for controlled drug delivery

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