A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zheng, Zhi;Lei, Cai;Liu, Hongbing;Jiang, Mingchao;Zhou, Zongtao;...

通讯作者：

Yu, C.-Y.;Wei, H.

作者机构：

[Lei, Cai; Liu, Hongbing; Wei, Hua; Zhao, Yuqi; Zheng, Zhi; Zhou, Zongtao; Yu, Cui-Yun; Jiang, Mingchao] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Sch, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Lei, Cai; Liu, Hongbing; Wei, Hua; Zhao, Yuqi; Zheng, Zhi; Zhou, Zongtao; Yu, Cui-Yun; Jiang, Mingchao] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Cui-Yun Yu; Hua Wei; Cui-Yun Yu Cui-Yun Yu Cui-Yun Yu; Hua Wei Hua Wei Hua Wei] H

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & School of Pharmaceutical Science, Hengyang Medical School, University of South China, 28 W Changsheng Road, Hengyang, Hunan, 421001 China

语种：

英文

关键词：

angiogenesis;injectable hydrogels;mitochondrial targeting;myocardial infarction;reactive oxygen species scavenging

期刊：

Advanced Healthcare Materials

ISSN：

2192-2640

年：

2022

卷：

期：

页码：

e2200990

DOI：

10.1002/adhm.202200990

基金类别：

This study was supported by the National Natural Science Foundation of China (81471777), the Natural Science Foundation of Hunan Province (2017JJ1024), and the Postgraduate Scientific Research Innovation Project of Hunan Province (CX20200911).

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant pathogenesis of early myocardial infarction (MI). However, only a few agents or strategies have been developed to improve mitochondrial dysfunction for the effective MI treatment. Herein, a reactive oxygen species (ROS)-responsive PAMB-G-TK/4-arm-PEG-SG hydrogel is developed for localized drug-loaded liposome delivery. Notably, the liposomes contain both elamipretide (SS-31) and sphingosine-1-phosphate (S1P), where SS-31 acts as an inhibitor of mitochondrial oxidative damage and S1P as a signaling molecule f...

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A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction

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