Microcystin-LR Combined with Cadmium Exposures and the Risk of Chronic Kidney Disease: A Case-Control Study in Central China

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Feng, Shuidong;Deng, Shuxiang;Tang, Yan;Liu, Ying;Yang, Yue;...

通讯作者：

Shen, Minxue(shenmx1988@csu.edu.cn);Yang, Fei(yangfeilong@126.com)

作者机构：

[Tang, Peng; Deng, Shuxiang; Liu, Ying; Feng, Shuidong; Yang, Fei; Tang, Yan] Univ South China, Sch Basic Med, Sch Publ Hlth, Hengyang Med Sch,Dept Epidemiol & Hlth Stat,Key L, Hengyang 421001, Peoples R China.

[Xu, Shuaishuai; Duan, Yanying; Shen, Minxue; Wei, Jia; Yang, Fei; Yang, Yue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Social Med & Hlth Management, Hunan Prov Key Lab Clin Epidemiol, Changsha 410000, Peoples R China.

[Lu, Yao] Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410000, Peoples R China.

[Pu, Yuepu; Liang, Geyu; Yang, Fei] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing 210000, Peoples R China.

[Chen, Xiang; Shen, Minxue] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha 410000, Peoples R China.

通讯机构：

[Shen, M.] H

[Yang, F.] D

Hunan Provincial Key Laboratory of Clinical Epidemiology, China

Department of Epidemiology and Health Statistics, China

语种：

英文

关键词：

microcystin-LR;chronic kidney disease;cadmium;case-control study;synergistic effect

期刊：

Environmental Science & Technology

ISSN：

0013-936X

年：

2022

卷：

期：

页码：

15818-15827

DOI：

10.1021/acs.est.2c02287

基金类别：

We thank all staff involved for their contribution to the design and conduct of this study. In addition, we sincerely thank the distinguished Professor Hongtu Xie’s group for participating in the designation of the journal cover and abstract graphic, which including Hongtu Xie, Jing Huang, Yu Zhu, Yong Yang, and Ling Peng from Solux College of Architecture and Design, University of South China. This study was supported by the Key Research and Development Projects in Hunan Province (2022SK2089, 2019SK2041), the Hunan Province Excellent Youth Fund (2020JJ3053), the Huxiang Youth Talent Program (2021RC3107), and the National Natural Science Foundation of China (81773393).

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

Increasing evidence indicates that exposure to microcystin-LR (MC-LR) can cause kidney damage. However, the association between MC-LR exposure and chronic kidney disease (CKD) risk in humans has not been studied. Therefore, we conducted a population-based case-control study involving 135 CKD cases and 135 matched controls in central China and analyzed the effects of MC-LR alone as well as combined with the known risk factor cadmium (Cd). Compared to the lowest quartile of MC-LR exposure, the highest quartile had a 6.56-fold (95% confidence inte...

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Microcystin-LR Combined with Cadmium Exposures and the Risk of Chronic Kidney Disease: A Case-Control Study in Central China

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