Genome-based analyses from four clinically-isolated strains refined the taxonomy of Proteus genomosp. 6 and revealed their underestimated role in gastrointestinal diseases

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Zhiyun;He, Jing;Liu, Xueqing;Huang, Linqian;Zeng, Zhou;...

通讯作者：

Peng, Yao;Cai, XC

作者机构：

[Zhang, Zhiyun; Liu, Xueqing] Cent Hosp Yongzhou, Dept Clin Lab, Yongzhou 425000, Peoples R China.

[Zhang, Zhiyun; Liu, Xueqing] Univ South China, Yongzhou Hosp, Dept Clin Lab, Yongzhou 425000, Peoples R China.

[He, Jing] Cent Hosp Yongzhou, Dept Pharm, Yongzhou 425000, Peoples R China.

[He, Jing] Univ South China, Yongzhou Hosp, Dept Pharm, Yongzhou 425000, Peoples R China.

[Huang, Linqian] Northeast Agr Univ, Coll Life Sci, Harbin 150030, Peoples R China.

通讯机构：

[Cai, XC ; Peng, Y] S

Shenzhen Univ, Gen Hosp, Dept Gastroenterol & Hepatol, Xueyuan RD 1298, Shenzhen 518071, Peoples R China.

语种：

英文

关键词：

Proteus genomosp. 6;Proteus columbae;Acute appendicitis;Antibiotic resistance;Virulence factor

期刊：

Gut Pathogens

ISSN：

1757-4749

年：

2025

卷：

期：

页码：

1-9

DOI：

10.1186/s13099-025-00701-8

基金类别：

This research was supported by the Shenzhen Science and Technology Program (grant number JCYJ20230808105208017), the Yongzhou City Instructive Science and Technology Plan Project (grant number 2023YZ091, 2024YZ062).

机构署名：

本校为其他机构

院系归属：

医学院

药学与生物科学学院

摘要：

BACKGROUND: Proteus spp. have long been recognized for their role in urinary tract infections, while recent evidence disclosed their implications in gastrointestinal diseases. Despite this, the taxonomy of clinically-derived Proteus spp., particularly those from gastrointestinal samples, remains understudied and is frequently mis-assigned, which limits our understanding of infections caused by these species. RESULTS: Four Proteus strains (i.e., DFP240708, LHD240705, TSJ240517 and WDL240414) were isolated from the appendiceal pus of patients wit...

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Genome-based analyses from four clinically-isolated strains refined the taxonomy of Proteus genomosp. 6 and revealed their underestimated role in gastrointestinal diseases

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