A ferritin-like protein with antioxidant activity in Ureaplasma urealyticum Microbial biochemistry, physiology and metabolism

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成果类型：

期刊论文

作者：

Dai, Guozhi;Li, Ranhui;Chen, Hongliang;Jiang, Chuanhao;You, Xiaoxing;...

通讯作者：

Wu, Yimou

作者机构：

[Jiang, Chuanhao; Wu, Yimou; Dai, Guozhi; You, Xiaoxing; Li, Ranhui] Univ South China, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China.

[Wu, Yimou; Dai, Guozhi; You, Xiaoxing; Li, Ranhui] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Chen, Hongliang; Dai, Guozhi] First Peoples Hosp Chenzhou, Dept Clin Lab, Chenzhou 42300, Hunan, Peoples R China.

[Wu, Yimou] Univ South China, Inst Pathogen Biol, Changsheng Rd 28, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Inst Pathogen Biol, Changsheng Rd 28, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Ureaplasma urealyticum;Ferritin;Reactive oxygen species;Antioxidant activity

期刊：

BMC Microbiology

ISSN：

1471-2180

年：

2015

卷：

期：

页码：

1-9

DOI：

10.1186/s12866-015-0485-6

基金类别：

This work was financially supported by a grant from Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (No. 2014–5) and the Science and Technology Planning Project of Hunan Province (Grant No. 2013TT2013), construct program of the key discipline in Hunan Province (No. 2011–75) and the Natural Science Foundation of China (31270218).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Ureaplasma urealyticum is a major pathogen associated with many diseases. The ability of U. urealyticum to protect itself from oxidative stress is likely to be important for its pathogenesis and survival, but its oxidative stress tolerance mechanisms remain unclear. This study investigates the antioxidant activity of a ferritin-like protein from U. urealyticum. Results: The uuferritin gene, which was up regulated when U. urealyticum was subjected to oxidative stress, was cloned from U. urealyticum and the corresponding recombinant p...

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A ferritin-like protein with antioxidant activity in Ureaplasma urealyticum Microbial biochemistry, physiology and metabolism

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