Disulfidptosis status influences prognosis and therapeutic response in clear cell renal cell carcinoma

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成果类型：

期刊论文

作者：

Deng, Weiming*;Xie, Zhenwei;Chen, Libo;Li, Wenjin;Li, Mingyong

通讯作者：

Deng, Weiming;Li, MY

作者机构：

[Li, Mingyong; Deng, Weiming; Chen, Libo; Deng, WM] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Urol, Hengyang, Hunan, Peoples R China.

[Xie, Zhenwei] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Kidney Transplantat, Guangzhou, Guangdong, Peoples R China.

[Li, Wenjin] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Endocrinol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Li, MY ; Deng, WM] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Urol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

WGCNA;clear cell renal cell carcinoma;disulfidptosis;prognostic score;system biology

期刊：

AGING-US

ISSN：

1945-4589

年：

2024

卷：

期：

页码：

1249-1275

DOI：

10.18632/aging.205405

基金类别：

FUNDING - Clinical Research Project of the University of South China [USCKF201902K01]

机构署名：

本校为第一且通讯机构

摘要：

Disulfidptosis is a recently identified type of programmed cell death. It is characterized by aberrant accumulation of intracellular disulfides. The clinical implications of disulfidptosis in clear cell renal cell carcinoma (ccRCC) remain unclear. A series of bioinformatics approaches were employed to analyze ten disulfidptosis-related molecules. Firstly, the expression patterns of the disulfidptosis-related molecules were different between normal and ccRCC tissues. A comprehensive cohort of patients with ccRCC was then assembled from three public databases and subjected to cluster analysis ba...

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Disulfidptosis status influences prognosis and therapeutic response in clear cell renal cell carcinoma

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