期刊论文

Ding, Dexin

英文

HEALTH PHYSICS

0017-9078

2019

116

6

749-759

10.1097/HP.0000000000001012

Acknowledgments—This project was sponsored by the Defense Industrial Technology Development Program (JCKY2016403C001), the Key Project of National Defense Basic Research (B3720132001), the National Natural Science Foundation of China (U1401231), China Postdoctoral Science Foundation (2014M562115), Hunan Provincial Educational Department Foundation (14C0998), Hunan Provincial Graduate Innovative Foundation (CX2015B386), and the Research Initiation Funding of University of South China for the Returned Scholars From Abroad (2014XQD46).

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Gamma radiation causes cell injury and leads to an increased risk of cancer, so it is of practical significance to identify biomarkers for gamma radiation. We used proteomic analysis to identify differentially expressed proteins in liver tissues of C57BL/6J mice treated with gamma radiation from 137Cs for 360 d. We confirmed obvious pathological changes in mouse liver tissues after irradiation. Compared with the control group, 74 proteins showed a fold change of ≥1.5 in the irradiated groups. We selected 24 proteins for bioinformatics analysis...