Long-term environmental levels of microcystin-LR exposure induces colorectal chronic inflammation, fibrosis and barrier disruption via CSF1R/Rap1b signaling pathway

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成果类型：

期刊论文

作者：

Yang, Yue;Wang, Hui;Wang, Xiaoyan;Chen, Ling;Liu, Wenya;...

通讯作者：

Fei Yang

作者机构：

[Feng, Xiangling; Chen, Jihua; Liu, Wenya; Yang, Fei; Yang, Yue; Chen, Mengshi] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha, Peoples R China.

[Wang, Hui; Deng, Shuxiang; Chu, Hanyu; Cao, Yi; Liu, Ying; Long, Dingxin; Cai, Danping; Cao, Deliang; Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang, Peoples R China.

[Wang, Xiaoyan] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.

[Chen, Ling] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang, Peoples R China.

[Wang, Chengkun] Univ South China, Sch Basic Med, Hengyang Med Sch, Dept Med Pathol, Hengyang, Peoples R China.

通讯机构：

[Fei Yang] H

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, China<&wdkj&>Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China

语种：

英文

关键词：

CSF1R;Chronic inflammation;Fibrosis;Intestinal injury;MC-LR

期刊：

Journal of Hazardous Materials

ISSN：

0304-3894

年：

2022

卷：

440

页码：

129793

DOI：

10.1016/j.jhazmat.2022.129793

基金类别：

This work was supported by the Key Project of Research and Development Plan of Hunan Province (2019SK2041, 2022SK2089); the Hunan Province Excellent Youth Fund (2020JJ3053); the Huxiang Youth Talent Support Program (2021RC3107); the National Natural Science Foundation of China (81773393); the Graduate Students Independent Exploration and Innovation Project of Central South University (2022ZZTS0246); the National Natural Science Foundation of China (82100537). CRediT authorship Contribution statement Fei Yang: Conceptualization, Formal analysis, Resources, Data curation, Writing – original draft, Writing – review & editing, Supervision, Project administration, acquisition. Yue Yang: Conceptualization, Software, Validation, Investigation, Writing – original draft, Writing – review & editing, Visualization. Hui Wang: Software, Formal analysis, Data Curation, Writing – original draft, Writing – review & editing, Visualization. Xiaoyan Wang: Resources, Writing – review & editing,

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Microcystin-LR (MC-LR) is a very common toxic cyanotoxins threating ecosystems and the public health. This study aims to explore the long-term effects and potential toxicity mechanisms of MC-LR exposure at environmental levels on colorectal injury. We performed histopathological, biochemical indicator and multi-omics analyses in mice with low-dose MC-LR exposure for 12 months. Long-term environmental levels of MC-LR exposure caused epithelial barrier disruption, inflammatory cell infiltration and an increase of collagen fibers in mouse colorectum. Integrated proteotranscriptomics revealed diff...

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Long-term environmental levels of microcystin-LR exposure induces colorectal chronic inflammation, fibrosis and barrier disruption via CSF1R/Rap1b signaling pathway

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