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Molecular mechanisms of secretory autophagy and its potential role in diseases

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成果类型:
期刊论文
作者:
Li, Qin;Peng, Guolong;Liu, Huimei;Wang, Liwen;Lu, Ruirui*;...
通讯作者:
Lu, Ruirui;Li, LF
作者机构:
[Lu, Ruirui; Liu, Huimei; Li, Lanfang; Li, Qin; Wang, Liwen; Li, LF; Lu, RR; Peng, Guolong] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Li, LF ; Lu, RR] U
Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Alzheimer's disease;Autophagy;COVID-19;Cancer;Secretory autophagy
期刊:
Life Sciences
ISSN:
0024-3205
年:
2024
卷:
347
页码:
122653
基金类别:
Acknowledgements Funding: This work was supported by the grants from the National Natural Science Foundation of China [Grant numbers: 81970431]; and the Hunan Provincial Natural Science Foundation of China [Grant numbers: 2023JJ50136 and Grant number: 2023JJ40563].
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Autophagy is a cellular degradation system that recycles or degrades damaged organelles, viral particles, and aggregated proteins through the lysosomal pathway. Autophagy plays an indispensable role in cellular homeostasis and communication processes. An interesting aspect is that autophagy also mediates the secretion of cellular contents, a process known as secretory autophagy. Secretory autophagy differs from macroautophagy, which sequesters recruited proteins, organelles, or viral particles into autophagosomes and degrades these sequesters in lysosomes, while the secretory autophagy pathway...

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