Proteome array of antibody responses to Chlamydia trachomatis infection in nonhuman primates

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成果类型：

期刊论文

作者：

Lu, Chunxue;Sun, Zhenjie;Chen, Hui;Chen, Lili;Zhu, Cuiming;...

通讯作者：

Peng, Bo;Zhong, Guangming

作者机构：

[Lu, Chunxue; Chen, Hui; Peng, Bo; Zhu, Cuiming; Chen, Chaoqun; Chen, Lili; Sun, Zhenjie] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

[Li, Changqing] Univ South China, Nanyue Biopharmaceut Co Ltd, Hunan Prov Innovat Training Base Postgrad, Hengyang 421001, Hunan, Peoples R China.

[Li, Changqing] Nanyue Biopharmaceut Co Ltd, Hengyang 421001, Hunan, Peoples R China.

[Peng, Bo] Univ South China, Hengyang Med Coll, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

[Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA.

通讯机构：

[Peng, Bo; Zhong, Guangming] U

Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Coll, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA.

语种：

英文

关键词：

Antibody;Chlamydia trachomatis;Primate;Proteome array

期刊：

Life Sciences

ISSN：

0024-3205

年：

2020

卷：

248

页码：

117444

DOI：

10.1016/j.lfs.2020.117444

基金类别：

This project was supported by the Natural Science Foundation of China (No. 81471969 & 81202374), the construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (No. 2014-5).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Aims: Nonhuman primates have been used to investigate pathogenic mechanisms and evaluate immune responses following Chlamydia trachomatis inoculation. This study aimed to systemically profile antibody responses to C. trachomatis infection in nonhuman primates. Materials and methods: Sera were obtained from 4 pig-tailed and 8 long-tailed macaques which were intravaginally or ocularly infected with live C. trachomatis organisms, and analyzed by C. trachomatis proteome array of antigens. Key findings: The sera from 12 macaques recognized total 172...

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Proteome array of antibody responses to Chlamydia trachomatis infection in nonhuman primates

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