Roles of long noncoding RNAs in bacterial infection

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wen, Yating;Chen, Hongliang;Luo, Fangzhen;Zhou, Hui;Li, Zhongyu*

通讯作者：

Li, Zhongyu

作者机构：

[Luo, Fangzhen; Li, Zhongyu; Chen, Hongliang; Wen, Yating] Univ South China, Hengyang Med Coll, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pathogen Biol,Hunan Prov Cooperat Innovat Ct, Hengyang 421001, Peoples R China.

[Chen, Hongliang] Chenzhou 1 Peoples Hosp, Dept Clin Microbiol Lab, Chenzhou 423000, Peoples R China.

[Zhou, Hui] Hunan Univ Chinese Tradit Med, Dept Lab Med, Affiliated Hosp 1, Changsha 410007, Peoples R China.

[Li, Zhongyu] Univ South China, Hengyang Med Coll, Pathogen Biol Inst, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, Zhongyu] U

Univ South China, Hengyang Med Coll, Pathogen Biol Inst, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Antibacterial immunity;Bacterial infection;Epigenetic regulation;Host-pathogen interaction;Long noncoding RNAs (lncRNAs)

期刊：

Life Sciences

ISSN：

0024-3205

年：

2020

卷：

263

期：

页码：

118579

DOI：

10.1016/j.lfs.2020.118579

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [32070189, 81772210, 81802022]; University of South China [2019-2]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [2014-5]; Hunan Provincial Innovation Foundation for Postgraduate [CX20190715]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Bacteria can induce significant alteration in the cell transcriptome and develop many strategies to modify immune signaling for its survival. In recent years, a new class of regulatory RNAs, long noncoding RNAs (lncRNAs), has been demonstrated to play an essential role in host gene expression. Growing literature indicate that lncRNAs function as positive or negative effectors on antibacterial immunity. On the one hand, the host regulates immune-related genes at epigenetic, transcriptional, and post-transcriptional levels by lncRNAs, thereby protecting itself from pathogen invasion. On the othe...

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Roles of long noncoding RNAs in bacterial infection

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