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Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy

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成果类型:
期刊论文
作者:
Lu, Li-qun;Tang, Ming-zhu;Qi, Zhi-hao;Huang, Shi-fang;He, Yong-qi;...
通讯作者:
Li, Lan-fang;Chen, Lin-xi
作者机构:
[Huang, Shi-fang; Chen, Lin-xi; Qi, Zhi-hao; He, Yong-qi; Li, Lan-fang; Tang, Ming-zhu; Li, LF; Chen, LX; Lu, Li-qun; Li, Dian-ke] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
通讯机构:
[Li, LF; Chen, LX] U
Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Autophagy;Cardiomyocytes hypertrophy;GOLPH3;Golgi apparatus;Golgi stress
期刊:
Life Sciences
ISSN:
0024-3205
年:
2020
卷:
253
期:
1
页码:
117700
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81470434, 81670265]
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Aims: Although previous studies elaborated that selective autophagy was involved in quality control of some organelles, including nucleus, mitochondria, the endoplasmic reticulum and peroxisomes, it remained unclear whether the selective autophagy of the Golgi apparatus (Golgiphagy) existed or not. Main methods: In this study, H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells were treated with autophagy inducers, Golgi stress inducers and cardiomyocytes hypertrophy stimulators. The Golgiphagy was evaluated by analysing the co-localization of Golgi...

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