Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiao, Xiao;Shen, Yingying;Yin, Liyang;He, Jun;Ni, Xiaoyu;...

通讯作者：

Peng, Xiuda;Zu, Xuyu

作者机构：

[Zhong, Jing; Chen, Xiguang; Yin, Liyang; Xiao, Xiao; Luo, Gang; Ni, Xiaoyu; Peng, Xiuda; Zu, Xuyu; Liu, Jianghua; Zhu, Wenbo; Shen, Yingying] Univ South China, Inst Clin Med, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Xiao] Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Pharm, Guangzhou, Guangdong, Peoples R China.

[He, Jun] Univ South China, Dept Spine Surg, Affiliated Nanhua Hosp, Hengyang, Hunan, Peoples R China.

通讯机构：

[Peng, XD; Zu, XY] U

Univ South China, Inst Clin Med, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Cell proliferation;Estrogen receptor alpha;Proteasomal degradation;ZBTB7A

期刊：

Life Sciences

ISSN：

0024-3205

年：

2019

卷：

239

期：

页码：

117042

DOI：

10.1016/j.lfs.2019.117042

基金类别：

Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province [A2017013]; Scientific Research Fund of Education Department of Hunan Province [18A255, 18C0473]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81972487, 81903652, 81773294]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ50552, 2019JJ80100, 2019JJ20014]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

AIMS: ZBTB7A, a transcriptional repressor, accelerates the breast cancer progression. Over 70% of breast cancer samples are identified as ER-alpha positive. Due to the function of ZBTB7A in ER-alpha positive breast cancer incompletely known, we aimed to determine the role of ZBTB7A in ER-alpha positive cancer and explore the underlying mechanisms. MAIN METHODS: In this study, the correlation between ZBTB7A and ER-alpha was confirmed by tissue microarray-based and TCGA database. Then, we explore if ZBTB7A maintains ER-alpha's level via targeting ER-alpha's expression or degradation. Finally, we...

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Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha

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