期刊论文

Li, Yukun;Wu, Daichao

英文

Life Sciences

0024-3205

2019

228

4

167-175

10.1016/j.lfs.2019.04.046

Obesity was one of the important aberrations in PCOS [54]. The study of PCOS patients, the majority showed an obesity and the appearance of male features. Their fats were characteristically accumulated in the abdominal wall and the visceral mesentery, which was more sensitive to catecholamine than insulin. Meanwhile, this type of body fat distribution could induce IR, hyperinsulinemia and abnormal glucose tolerance [55]. Recently, it was reported that high circulating FFA levels have been shown to increase the production of all androgens in normal women [56]. Adiponectin, a 244-amino acid protein with an important function of increasing liver insulin sensitivity [57], is decreased in PCOS patients compared to normal girl [58]. It can upregulate the levels of SHBG to reduce the content of androgen in HepG2 cell, which is attributed to that adiponectin activates AMPK to reduce the mRNA and protein levels of acetyl-coenzyme A (CoA) carboxylase (ACC) and to enhance the levels of carnitine palmitoyltransferase I (CPTI) and peroxisomal acyl-CoA oxidase (ACOX). These changes of enzymes mediated by adiponectin decrease free FA and triglycerides (TGs) levels, resulting in turn upregulated HNF-4 [59] which upregulates the production of SHBG [36].

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Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female infertility around the world. It is no longer considered simply as a disease of ovary. Now researchers growing awareness of the multisystem features of this disease. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis (HPOA) function disorders. This syndrome results in hyperandrogenemia (HA), hyperinsulinemia/insulin resistance (IR), increased estrone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) ratio imbalance, infertility, cardiovascular dise...