Salinomycin-induced autophagy blocks apoptosis via the ATG3/AKT/mTOR signaling axis in PC-3 cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Yunsheng;Li, Fang;Liu, Luogen;Jiang, Hongtao;Jiang, Xiaorong;...

通讯作者：

Wang, Yi

作者机构：

[Wang, Yi; Zhang, Yunsheng; Ge, Xin; Liu, Luogen] Univ South China, Affiliated Hosp 2, Clin Res Inst, 35 Jiefang Ave, Hengyang 421001, Hunan, Peoples R China.

[Li, Fang] Hunan Polytech Environm & Biol, Coll Nursing, Hengyang 421005, Peoples R China.

[Jiang, Hongtao] Univ South China, Affiliated Hosp 2, Dept Urol, Hengyang 421001, Peoples R China.

[Wang, Zhenggen; Zhang, Li; Jiang, Xiaorong] Univ South China, Affiliated Hosp 2, Dept Gastroenterol, Hengyang 421001, Peoples R China.

[Cao, Jingsong] Univ South China, Med Coll, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, Yi] U

Univ South China, Affiliated Hosp 2, Clin Res Inst, 35 Jiefang Ave, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ATG3/AKT/mTOR signaling axis;Autophagy;PC-3 cells;Salinomycin

期刊：

Life Sciences

ISSN：

0024-3205

年：

2018

卷：

207

页码：

451-460

DOI：

10.1016/j.lfs.2018.06.034

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81241090, 81372378]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ3462, 2016WK2013]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Aims: This study evaluated the mechanism by which salinomycin-induced autophagy blocks apoptosis in PC-3 prostate cancer cells. Main methods: The anti-cancer effects of salinomycin in PC-3 cells were confirmed by flow cytometry, JC-1 staining and western blotting. Then, the autophagic effects were measured by western blotting, GFP-LC3 puncta formation assay, immunofluorescence staining and electron microscopy. Furthermore, we used lentivirus-mediated shRNA to silence ATG3, ATG5 and ATG7 expression in PC-3 cells to investigate the regulatory mec...

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Salinomycin-induced autophagy blocks apoptosis via the ATG3/AKT/mTOR signaling axis in PC-3 cells

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