National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670401]; Natural Sciences Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ6133]; Scientific Research Innovation Program of Post-graduate in Hunan Province [CX2017B554]; Zhengxiang Scholar (Xiangyang Tang) Program of the University of South China; Construct Program of the Key Discipline in Hunan Province (Basic Medicine Sciences in University of South China)
机构署名：
本校为第一且通讯机构
院系归属：
医学院
药学与生物科学学院
摘要：
Atherosclerosis is characterized by the accumulation of lipids and deposition of fibrous elements in the vascular wall, which is the primary cause of cardiovascular diseases. Adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor of energy metabolism that regulates multiple physiological processes, including lipid and glucose metabolism and the normalization of energy imbalances. Overwhelming evidence indicates that AMPK activation markedly attenuates atherosclerosis development. Autophagy inhibits cell apoptosis and inflammation and promotes cholesterol efflux and effer...
