Sodium-glucose cotransporter 2 inhibitors and cancer: a systematic review and meta-analysis

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成果类型：

期刊论文

作者：

Xu, B.;Kang, B.;Li, S.;Fan, S.;Zhou, J.

通讯作者：

Zhou, J

作者机构：

[Li, S.; Xu, B.; Kang, B.; Zhou, J.; Fan, S.] Univ South China, Affiliated Hosp 1, Hunan Prov Clin Med Res Ctr Drug Evaluat Major Chr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Li, S.; Xu, B.; Kang, B.; Zhou, J.; Fan, S.] Univ South China, Affiliated Hosp 1, Hengyang Clin Pharmacol Res Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Li, S.; Xu, B.; Kang, B.; Zhou, J.; Fan, S.] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang Key Lab Clin Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Li, S.; Xu, B.; Kang, B.; Zhou, J.; Fan, S.] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Pharm Dept, Hengyang 421001, Hunan, Peoples R China.

[Xu, B.; Zhou, J.] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhou, J ] U

Univ South China, Affiliated Hosp 1, Hunan Prov Clin Med Res Ctr Drug Evaluat Major Chr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Clin Pharmacol Res Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang Key Lab Clin Pharmacol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Pharm Dept, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Sodium-glucose cotransporter 2 inhibitor;Cancer;Dapagliflozin;Bladder cancer;Breast cancer;Renal cancer

期刊：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

ISSN：

0391-4097

年：

2024

页码：

1-16

DOI：

10.1007/s40618-024-02351-0

基金类别：

This study was supported by the NSFC (82003872), Natural Science Foundation of Hunan Province (2022JJ50163, 2023JJ20034), Scientific Research Fund Project of Hunan Provincial Health Commission (20201973), Central government funds for guiding local scientific and Technological Development (2021QZY016), Hunan Province Clinical Medical Technology Innovation Guidance Project (2020SK51823, 2021SK51828, 2021SK51823), Hunan Provincial Clinical Medical Research Center for Drug Evaluation of major chronic diseases (2023SK4040). The science and technology innovation Program of Hunan Province (2023RC3173).

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本校为第一且通讯机构

摘要：

BACKGROUND: The effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cancer has yet to be fully elucidated. OBJECTIVE: This systematic review and meta-analysis investigated the effects of SGLT2 inhibitors on cancer. METHODS: We searched the PubMed and ClinicalTrials.gov databases up to July 15, 2023, to identify eligible randomized, double-blind, placebo-controlled trials that lasted at least ≥24weeks. The primary outcome was the overall cancer incidence, and the secondary outcomes were the incidences of various types of cancer. We u...

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Sodium-glucose cotransporter 2 inhibitors and cancer: a systematic review and meta-analysis

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