Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Zhuo-Jun;Zou, Wei;Yuan, Juan;Zhang, Ping;Tian, Ying;...

通讯作者：

Tang, Xiao-Qing

作者机构：

[Xiao, Zhi-Fang; Tang, Zhuo-Jun; Tang, Xiao-Qing; Zou, Wei; Zhang, Ping; Yuan, Juan] Univ S China, Nanhua Affiliated Hosp, Dept Neurol, Hengyang, Hunan, Peoples R China.

[Wei, Hai-Jun; Tang, Zhuo-Jun; Tang, Xiao-Qing; Li, Mang-Hong; Yuan, Juan] Univ S China, Inst Neurosci, Hengyang, Hunan, Peoples R China.

[Tian, Ying] Univ S China, Dept Biochem, Coll Med, Hengyang, Hunan, Peoples R China.

[Wei, Hai-Jun; Tang, Xiao-Qing; Li, Mang-Hong; Zhang, Ping] Univ S China, Key Lab Cognit Disorders & Neurodegenerat Dis, Hengyang, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ S China, Dept Physiol, Coll Med, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing] U

Univ S China, Dept Physiol, Coll Med, 28 W Changsheng Rd, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

anxiety;depression;diabetes;hydrogen sulfide;oxidative stress;rat;streptozotocin

期刊：

BEHAVIOURAL PHARMACOLOGY

ISSN：

0955-8810

年：

2015

卷：

期：

页码：

427-435

DOI：

10.1097/FBP.0000000000000143

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371485]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [12JJ9032]; Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Depression is highly prevalent in individuals with diabetes, and depressive symptoms are less responsive to current antidepressant therapies. Oxidative stress plays a major role both in the pathogenesis of diabetes and in major depression and anxiety disorders. Hydrogen sulfide (H2S), the third gaseous mediator, is a novel signaling molecule in the brain that has both antioxidative activity and antidepressant-like and anxiolytic-like effects. We hypothesized that H2S could produce antidepressant-like and anxiolytic-like effects in diabetic patients through its antioxidative effect. To test thi...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问