MicroRNA-27 Prevents Atherosclerosis by Suppressing Lipoprotein Lipase-Induced Lipid Accumulation and Inflammatory Response in Apolipoprotein E Knockout Mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xie, Wei;Li, Liang;Zhang, Min;Cheng, Hai-Peng;Gong, Duo;...

通讯作者：

Yin, Wei-Dong;Tang, Chao-Ke

作者机构：

[Gong, Duo; Cheng, Hai-Peng; He, Ping-Ping; Ouyang, Xin-Ping; Lan, Gang; Zhang, Min; Liu, Dan; Tang, Chao-Ke; Yin, Wei-Dong; Tang, CK; Tan, Yu-Lin; Zhao, Zhen-Wang; Li, Liang; Xie, Wei; Yao, Feng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Med Res Ctr, Hengyang, Hunan, Peoples R China.

[Lv, Yun-Cheng; Xie, Wei] Univ South China, Lab Clin Anat, Hengyang, Hunan, Peoples R China.

[Li, Liang] Univ South China, Dept Pathophysiol, Hengyang, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta,Cumming Sch Med, Hosp Dr NW, Calgary, AB, Canada.

通讯机构：

[Yin, WD; Tang, CK] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Med Res Ctr, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Macrophages;Atherosclerosis;Lipids;Cytokines;Inflammation;Cholesterol;Cytokine therapy;Small interfering RNA

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2016

卷：

期：

页码：

e0157085

DOI：

10.1371/journal.pone.0157085

基金类别：

National Natural Sciences Foundation of China, ChinaNational Natural Science Foundation of China (NSFC) [81570408, 81270269, 81170278]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Atherosclerotic lesions are lipometabolic disorder characterized by chronic progressive inflammation in arterial walls. Previous studies have shown that macrophage-derived lipoprotein lipase (LPL) might be a key factor that promotes atherosclerosis by accelerating lipid accumulation and proinflammatory cytokine secretion. Increasing evidence indicates that microRNA-27 (miR-27) has beneficial effects on lipid metabolism and inflammatory response. However, it has not been fully understood whether miR-27 affects the expression of LPL and subsequent development of atherosclerosis in apolipoprotein...

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MicroRNA-27 Prevents Atherosclerosis by Suppressing Lipoprotein Lipase-Induced Lipid Accumulation and Inflammatory Response in Apolipoprotein E Knockout Mice

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