Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Yuanjun;Huang, Yumeng;Yang, Zhangsheng;Sun, Yina;Gong, Siqi;...

通讯作者：

Zhong, Guangming

作者机构：

[Liu, Yuanjun; Yang, Zhangsheng; Baseman, Joel; Huang, Yumeng; Gong, Siqi; Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.

[Liu, Quanzhong; Hou, Shuping] Tianjin Med Univ Gen Hosp, Dept Dermatovenereol, Tianjin, Peoples R China.

[Sun, Yina] Tianjin Med Univ, Hosp & Tianjin Inst Endocrinol, Key Lab Hormones & Dev Minist Health, Metab Dis, Tianjin, Peoples R China.

[Li, Zhongyu; Wu, Yimou; Chen, Chaoqun] Univ South China, Dept Microbiol & Immunol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zhong, Guangming] U

Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.

语种：

英文

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2014

卷：

期：

页码：

5327-5335

DOI：

10.1128/IAI.02576-14

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic plasmid that encodes eight genes designated pgp1 to pgp8. To identify the plasmid-encoded pathogenic determinants, we evaluated C. muridarum transformants deficient in the plasmid-borne gene pgp3, -4, or -7 for induction of hydrosalpinx. C. muridarum transformants with an in-frame deletion of either pgp3 or -4 but not -7 failed to induce hydrosalpinx. The deletion mutant phenotype was reproduced by using transformants with ...

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Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice

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