TGF-β signaling and microRNA cross-talk regulates abdominal aortic aneurysm progression

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成果类型：

期刊论文

作者：

Tang, Ying;Fan, Wenjing;Zou, Bu;Yan, Wei;Hou, Yangfeng;...

通讯作者：

Qu, Shunlin

作者机构：

[Hou, Yangfeng; Zou, Bu; Yan, Wei; Fan, Wenjing; Jiang, Zhisheng; Qu, Shunlin; Tang, Ying] Univ South China, Key Lab Arteriosclerol Hunan Prov, Hunan Int Sci & Technol Cooperat Base Arterioscle, Pathophysiol Dept,Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

[Fan, Wenjing] Univ South China, Affiliated Hosp 2, Emergency Dept, Hengyang City 421001, Hunan, Peoples R China.

[Hou, Yangfeng; Zou, Bu; Yan, Wei; Tang, Ying] Univ South China, Hengyang Med Coll, Clin Dept, Hengyang 421001, Peoples R China.

[Agyare, Oware Kwabena] Univ South China, Int Coll, Hengyang Med Sch, Hengyang City 421001, Hunan, Peoples R China.

通讯机构：

[Qu, Shunlin] U

Univ South China, Key Lab Arteriosclerol Hunan Prov, Hunan Int Sci & Technol Cooperat Base Arterioscle, Pathophysiol Dept,Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

TGF-β signaling pathway;abdominal aortic aneurysms;microRNA

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2021

卷：

515

页码：

90-95

DOI：

10.1016/j.cca.2020.12.031

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670424, 81900424]; National Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ2345, 2019JJ40258, 2019JJ50502]; Scientific Research Fund of Hunan Provincial Health and Family Planning Commission [B20180058, B20180874]; project of "Research Study and Innovative Experiment Program for College Students" in University of South China [2018XJXZ375, 2019131]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Abdominal aortic aneurysms (AAA) are permanent and irreversible local dilatations of the abdominal aortic wall. Recent data indicate that the transforming growth factor-beta (TGF-beta) signaling pathway exerts a protective effect on the development of AAA. Some dysregulated microRNAs (miRNA) also appear involved in the expansion of AAA and miRNA-based therapeutics have been shown to effectively inhibit this process. New evidence has revealed that TGF-beta signaling and miRNA interaction may of physiologic and pathophysiologic significance including the progression of AAA. As such, miRNA that r...

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TGF-β signaling and microRNA cross-talk regulates abdominal aortic aneurysm progression

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