Altered regional homogeneity in patients with corneal ulcer: A resting-state functional MRI study

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成果类型：

期刊论文

作者：

Xu, Man-Wei;Liu, Hui-Min;Tang, Gang;Su, Ting;Xiang, Chu-Qi;...

通讯作者：

Shao, Yi

作者机构：

[Liu, Wen-feng; Shao, Yi; Wu, Wei; Min, You-Lan; Xu, Xiao-Wei; Lin, Qi; Xu, Man-Wei; Xiang, Chu-Qi; Li, Biao; Gao, Gui-Ping] Nanchang Univ, Jiangxi Prov Ocular Dis Clin Res Ctr, Affiliated Hosp 1, Dept Ophthalmol, Nanchang, Jiangxi, Peoples R China.

[Tang, Gang; Liu, Hui-Min] Univ South China, Dept Ophthalmol, Hengyang, Peoples R China.

[Su, Ting] Xiamen Univ, Fujian Prov Key Lab Ophthalmol & Visual Sci, Eye Inst, Xiamen, Fujian, Peoples R China.

通讯机构：

[Shao, Yi] N

Nanchang Univ, Jiangxi Prov Ocular Dis Clin Res Ctr, Affiliated Hosp 1, Dept Ophthalmol, Nanchang, Jiangxi, Peoples R China.

语种：

英文

关键词：

Corneal Ulcer;regional homogeneity;functional MRI (fMRI);resting state;Brain activity

期刊：

Frontiers in Neuroscience

ISSN：

1662-4548

年：

2019

卷：

期：

JUL

页码：

418703

DOI：

10.3389/fnins.2019.00743

基金类别：

This study was supported by the National Natural Science Foundation of China (Nos. 81660158, 81160118, and 81400372); the Natural Science Key Project of Jiangxi Province (No. 20161ACB21017); the Youth Science Foundation of Jiangxi Province (No. 20151BAB215016); the Technology and Science Foundation of Jiangxi Province (No. 20151BBG70223); and the Health Development Planning Commission Science Foundation of Jiangxi Province (No. 20175116).

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摘要：

Objective: To investigate the potential regional homogeneity (ReHo) brain activity changes in patients with corneal ulcer (CU) and their possible relationship with clinical symptoms. Materials and Methods: Forty patients with CU (26 men and 14 women), and 40 healthy controls (HCs) (26 men and 14 women) closely matched in age, sex, and weight underwent resting-state functional MRI scans, respectively. The ReHo method was applied to evaluate synchronous neural activity changes. Receiver operating characteristic curve (ROC curve) was used to show high test-retest stability and high degree of sens...

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Altered regional homogeneity in patients with corneal ulcer: A resting-state functional MRI study

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