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Double‐strand DNA break repair: molecular mechanisms and therapeutic targets

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成果类型:
期刊论文
作者:
Tan, Jinpeng;Sun, Xingyao;Zhao, Hongling;Guan, Hua;Gao, Shanshan;...
作者机构:
[Sun, Xingyao; Tan, Jinpeng; Zhou, Ping-Kun] Hengyang Medical College University of South China Hengyang Hunan Province China
[Zhao, Hongling; Guan, Hua; Sun, Xingyao; Tan, Jinpeng; Gao, Shanshan; Zhou, Ping-Kun] Department of Radiation Biology Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation Medicine Beijing China
语种:
英文
关键词:
DSB repair;HR;Ku70/80 heterodimer/DNA–PKcs (DNA–PK);MRN complex;NHEJ;Therapeutic targets
期刊:
MedComm
ISSN:
2688-2663
年:
2023
卷:
4
期:
5
页码:
e388
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Double‐strand break (DSB) is a critical DNA damage induced by ionizing radiation, and which is an actuating signal triggering cancer cell death in tumor radiotherapy. In mammalian cells, nonhomologous end‐joining (NHEJ) and homologous recombination (HR) are the two main pathways of DNA DSB repair, and both cooperate and compete with each other to promote efficient repair. Many regulatory factors play essential roles in the DSB repair pathway. For example, the MRE11–RAD50–NBS1 (MRN) complex and the Ku70/80 heterodimer/DNA–PKcs (DNA–PK) com...

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