Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of uqcrc1

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zeng, Junfa;Tao, Jun;Xia, Linzhen;Zeng, Zhaolin;Chen, Jiaojiao;...

通讯作者：

Wang, Zuo(smt121101@163.com)

作者机构：

[Chen, Jiaojiao; Tao, Jun; Liu, Lushan; Xia, Linzhen; Wang, Zuo; Zeng, Junfa] Univ South China, Hengyang Med Coll, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, Hengyang 421001, Hunan, Peoples R China.

[Zeng, Junfa] Univ South China, Affiliated Hosp 2, Hengyang, Peoples R China.

[Zeng, Zhaolin] Chongqing Med Univ, Peoples Hosp Nanchuan, Dept Cardiol, Chongqing 408499, Peoples R China.

[Meng, Jun] Univ South China, Funct Dept, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wang, Z.] I

Institute of Cardiovascular Disease, China

语种：

英文

关键词：

atherosclerosis;melatonin;NLRP3;UQCRC1;ROS;athérosclérose;mélatonine;NLRP3;UQCRC1;DRO

期刊：

BIOCHEMISTRY AND CELL BIOLOGY

ISSN：

0829-8211

年：

2021

卷：

期：

页码：

339-347

DOI：

10.1139/bcb-2020-0279

基金类别：

This study was supported by the National Natural Science Foundation of China (No. 81070221). We thank the University of South China for use of their research facilities.

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Atherosclerosis (AS) is a chronic inflammatory disease that involves cell death and endothelial dysfunction. Melatonin is an endocrine hormone with anti-inflammatory and anti-AS effects. However, the underlying molecular mechanisms for the anti-AS effects of melatonin are unknown. A previous study has shown that pyroptosis plays a detrimental role in the development of AS, therefore, this study was designed to investigate the anti-pyroptotic effects and potential mechanisms of melatonin in atherosclerotic endothelium. Our results show that mela...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of uqcrc1

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问