Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study

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成果类型：

期刊论文

作者：

Yang, Fan;Liu, Ru;He, Sheng;Ruan, Sijie;He, Binghua;...

通讯作者：

Pan, LH

作者机构：

[Pan, Linghui; Liu, Ru; Yang, Fan; Pan, LH; Li, Junda; He, Sheng] Guangxi Med Univ Canc Hosp, Dept Anesthesiol, Nanning, Guangxi Provinc, Peoples R China.

[Yang, Fan; He, Binghua; Ruan, Sijie] Cent Hosp Shaoyang, Dept Anesthesiol, Shaoyang, Hunan Province, Peoples R China.

[Pan, Linghui; Yang, Fan; Pan, LH] Guangxi Key Lab Basic Sci & Prevent Perioperat Org, Nanning, Guangxi Provinc, Peoples R China.

[Pan, Linghui; Yang, Fan; Pan, LH] Guangxi Clin Res Ctr Anesthesiol, Nanning, Guangxi Provinc, Peoples R China.

[Pan, Linghui; Yang, Fan; Pan, LH] Guangxi Engn Res Ctr Tissue & Organ Injury & Repai, Nanning, Guangxi Provinc, Peoples R China.

通讯机构：

[Pan, LH ] G

Guangxi Med Univ Canc Hosp, Dept Anesthesiol, Nanning, Guangxi Provinc, Peoples R China.

Guangxi Key Lab Basic Sci & Prevent Perioperat Org, Nanning, Guangxi Provinc, Peoples R China.

Guangxi Clin Res Ctr Anesthesiol, Nanning, Guangxi Provinc, Peoples R China.

Guangxi Engn Res Ctr Tissue & Organ Injury & Repai, Nanning, Guangxi Provinc, Peoples R China.

语种：

英文

关键词：

Mendelian randomization;Circadian Rhythm;Brain Cortex;Causal effect;Morningness

期刊：

Frontiers in Neuroscience

ISSN：

1662-4548

年：

2023

卷：

页码：

1222551

DOI：

10.3389/fnins.2023.1222551

基金类别：

This study was supported by the Health Commission of Hunan Province (Grant no. 202204113461 on FY) and the Natural Science Foundation of Hunan Province (Grant no. 2021JJ70046 on BH).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Introduction: Numerous studies have suggested a connection between circadian rhythm and neurological disorders with cognitive and consciousness impairments in humans, yet little evidence stands for a causal relationship between circadian rhythm and the brain cortex. Methods: The top 10,000 morningness-related single-nucleotide polymorphisms of the Genome-wide association study (GWAS) summary statistics were used to filter the instrumental variables. GWAS summary statistics from the ENIGMA Consortium were used to assess the causal relationship b...

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Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study

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