MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

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成果类型：

期刊论文

作者：

He, Ping-Ping;Ouyang, Xin-Ping;Tang, Yan-Yan;Liao, Li;Wang, Zong-Bao;...

通讯作者：

Yin, Wei-Dong

作者机构：

[Huang, Liang; Wu, Jian-Feng; Tang, Yu Lin; Liu, Xiang-Yu; He, Ping-Ping; Ouyang, Xin-Ping; Tian, Guo-Ping; Chen, Wu-Jun; Peng, Juan; Zhang, Min; Zhao, Guo-Jun; Li, Yuan; Lv, Yun-Cheng; Tang, Chao-Ke; Yin, Wei-Dong; Xie, Wei; Tang, Yan-Yan; Yao, Feng] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Liao, Li; He, Ping-Ping] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Ouyang, Xin-Ping] Univ South China, Coll Med, Inst Neurosci, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zong-Bao; Yin, Wei-Dong] Univ South China, Pharm & Biol Sci Coll, Hengyang 421001, Hunan, Peoples R China.

[Tian, Guo-Ping] Univ South China, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yin, Wei-Dong] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Human THP-1 macrophages;LPL;MiR-590

期刊：

Biochimie

ISSN：

0300-9084

年：

2014

卷：

106

页码：

81-90

DOI：

10.1016/j.biochi.2014.08.003

基金类别：

The authors gratefully acknowledge the financial supports from the National Natural Sciences Foundation of China ( 81300158 , 81270269 ), Aid Program for Science and Technology Department of Human Province （ 2013FJ3027 ）, Outstanding Young Aid Program for Education Department of Human Province （ 13B103 ）, Aid Program for Science and Technology Bureau of HengYang City （ 2013KS20 , 2013KS25 ）, Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions (2008-244) of Hunan Province, and the Construct Program of the Key Discipline in Hunan Province, China.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

Background: Accumulating evidence suggests that microRNA-590 (miR-590) has protective effects on cardiovascular diseases, but the mechanism is unknown. Interestingly, previous studies from our laboratory and others have shown that macrophage-derived lipoprotein lipase (LPL) might accelerate atherosclerosis by promoting lipid accumulation and inflammatory response. However, the regulation of LPL at the post-transcriptional level by microRNAs has not been fully understood. In this study, we explored whether miR-590 affects the expression of LPL and its potential subsequent effects on lipid accum...

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MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

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