Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Peng, Zhixin;Li, Xiaoheng;Li, Jun;Dong, Yuan;Gao, Yuhao;...

通讯作者：

Yuan, Zengqiang;Cheng, Jinbo

作者机构：

[Peng, Zhixin; Yuan, Zengqiang] Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang 421001, Peoples R China.

[Li, Xiaoheng; Gao, Yuhao; Peng, Zhixin; Yuan, Zengqiang] Beijing Inst Basic Med Sci, Brain Sci Ctr, 27 Taiping Rd, Beijing 100850, Peoples R China.

[Li, Jun] Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China.

[Dong, Yuan] Qingdao Univ, Inst Brain Sci & Dis, Coll Med, Qingdao 266071, Peoples R China.

[Yan, Meichen; Yuan, Zengqiang; Cheng, Jinbo; Liao, Yajin] Minzu Univ China, Coll Life & Environm Sci, Ctr Translat Neurosci, Beijing 100081, Peoples R China.

通讯机构：

[Yuan, Zengqiang] I

[Cheng, Jinbo] C

Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, 421001, China.

The Brain Science Center, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing, 100850, China.

Center on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China, Beijing, 100081, China.

语种：

英文

关键词：

Dlg1;Microglia;Neuroinflammation;Depression

期刊：

神经科学通报

ISSN：

1673-7067

年：

2021

卷：

期：

页码：

1671-1682

DOI：

10.1007/s12264-021-00765-x

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82071218, 81630026, 81930029]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization and the function of K(+) channels, which are reported to regulate the activation of microglia. However, little is known about the role of Dlg1 in microglia and the maintenance of central nervous system homeostasis. In this study, we found that Dlg1 knockdown suppressed lipopolysaccharide (LPS)-induced inflammation by do...

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Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

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