Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population

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成果类型：

期刊论文

作者：

Luo, Chao;Liu, Junyan;Wang, Xu;Mao, Xiaoyuan;Zhou, Honghao;...

通讯作者：

Liu, Zhaoqian

作者机构：

[Wang, Xu; Liu, Zhaoqian; Mao, Xiaoyuan; Zhou, Honghao; Luo, Chao] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

[Wang, Xu; Liu, Zhaoqian; Mao, Xiaoyuan; Zhou, Honghao; Luo, Chao] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China.

[Luo, Chao] Cent S Univ, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.

[Liu, Junyan] Univ South China, Dept Orthopaed, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

[Liu, Zhaoqian; Zhou, Honghao] Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Liu, Zhaoqian] C

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Pharmacogenetic;Antipsychotic;Weight gain;Single nucleotide polymorphism;Schizophrenia

期刊：

神经科学通报

ISSN：

1673-7067

年：

2019

卷：

期：

页码：

561-580

DOI：

10.1007/s12264-018-0323-6

基金类别：

National Basic Research Development Program of ChinaNational Basic Research Program of China [2016YFC1306900, 2016YFC0905002]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573508]; Open Foundation of Innovative Platform in Colleges and University of Hunan Province, China [[2015]54]; Clinical Research Fund of Peking University Unamed-Central South University Xiangya Hospital [xywm2015I16]

机构署名：

本校为其他机构

摘要：

Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. We determined that > 25 single-nucleotide polymorphism...

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