期刊论文

Li, Lanfang

英文

神经科学通报

1673-7067

2017

33

3

354-356

10.1007/s12264-017-0116-3

supported by the National Natural Science Foundation of China（81470434,81503074,and81670265）； the Science and Technology Project of Hunan Province,China（2015RS4040）； the Administration of Traditional Chinese Medicine of Hunan Province,China（201578）； the Health and Family-planning Commission of Hunan Province,China（B2015-48）；

本校为第一且通讯机构

Recently, Richter et al. [1] revealed the potential functions of the interaction between the serine/threonine kinase Tank-binding kinase 1 (TBK1) and the autophagy receptor optineurin (OPTN). The TBK1-OPTN axis targets damaged mitochondria for degradation via PINK1/parkin-mediated mitophagy [2, 3]. Indeed, TBK1 can phosphorylate OPTN at Ser177, Ser473, or Ser513 to enhance the binding capacity of OPTN with poly-ubiquitin (poly-UB) chains. Conversely, binding of poly-UB chains to OPTN is essential for the efficient recruitment and activation of ...

Recently,Richter et al.[1]revealed the potential functions of the interaction between the serine/threonine kinase Tank-binding kinase 1（TBK1）and the autophagy receptor optineurin（OPTN）.The TBK1-OPTN axis targets damaged mitochondria for degradation via PINK1/parkin-mediated mitophagy[2,3].Indeed,TBK1 can phosphorylate OPTN at Ser177,Ser473,or Ser513 to enhance the binding capacity of OPTN with poly-ubiquitin（poly-UB）chains.Converse...