期刊论文

Wang, Zuo

英文

International Journal of Biological Macromolecules

0141-8130

2017

98

637-645

10.1016/j.ijbiomac.2017.02.025

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Construct Program of the Key Discipline in Hunan Province

本校为第一且通讯机构

Lipoprotein(a)[Lp(a)] is a risk factor for coronary heart diseases. However, the metabolism of this protein remains poorly understood. Efficient and specific drugs that can decrease high plasma levels of Lp(a) have not been developed yet. Vitamin C is responsible for maintaining the catalytic activity of a group of iron and 2-oxoglutarate (20G)-dependent dioxygenases and induces the generation of 5-hydroxymethylcytosine (5hmC) via Ten-eleven translocation (Tet) dioxygenases. In addition, It has been reported vitamin C deficiency induces atherosclerosis and increases Lp(a) and apo(a) plasma lev...