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Unlocking the secrets of Cardiac development and function: the critical role of FHL2

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成果类型:
期刊论文
作者:
Jiang, Tingting;Zeng, Qun;Wang, Jing
通讯作者:
Wang, J
作者机构:
[Jiang, Tingting] Univ South China, Hengyang Med Sch, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang 421000, Peoples R China.
[Zeng, Qun] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421000, Peoples R China.
[Wang, Jing] Changsha Med Univ, Hunan Prov Key Lab Tradit Chinese Med Agr Biogenom, Changsha 410219, Peoples R China.
[Wang, Jing] Changsha Med Univ, Hunan Prov Univ Key Lab Fundamental & Clin Res Fun, Changsha 410219, Peoples R China.
[Wang, Jing] Changsha Med Univ, Clin Coll 1, Changsha 410219, Peoples R China.
通讯机构:
[Wang, J ] C
Changsha Med Univ, Hunan Prov Key Lab Tradit Chinese Med Agr Biogenom, Changsha 410219, Peoples R China.
Changsha Med Univ, Hunan Prov Univ Key Lab Fundamental & Clin Res Fun, Changsha 410219, Peoples R China.
Changsha Med Univ, Clin Coll 1, Changsha 410219, Peoples R China.
语种:
英文
关键词:
FHL2;LIM;Cardiac;Contractility;Hypertrophy;Fibrosis
期刊:
Molecular and Cellular Biochemistry
ISSN:
0300-8177
年:
2025
卷:
480
期:
4
页码:
2143-2157
基金类别:
This work was supported by the Natural Science Foundation of Hunan Province (No.2024JJ5325), the Excellent Youth Project of Hunan Provincial Education Department (No. 22B0411).
机构署名:
本校为第一机构
院系归属:
化学化工学院
医学院
药学与生物科学学院
摘要:
FHL2 (Four-and-a-half LIM domain protein 2) is a crucial factor involved in cardiac morphogenesis, the process by which the heart develops its complex structure. It is expressed in various tissues during embryonic development, including the developing heart, and has been shown to play important roles in cell proliferation, differentiation, and migration. FHL2 interacts with multiple proteins to regulate cardiac development as a coactivator or a corepressor. It is involved in cardiac specification and determination of cell fate, cardiomyocyte growth, cardiac remodeling, myofibrillogenesis, and ...

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