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Unlocking the secrets of Cardiac development and function: the critical role of FHL2

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成果类型:
期刊论文
作者:
Tingting Jiang;Qun Zeng;Jing Wang*
通讯作者:
Jing Wang
作者机构:
[Tingting Jiang] Department of Clinical Laboratory, Hengyang Medical School, the Affiliated Nanhua Hospital, University of South China, Hengyang, 421000, China
[Qun Zeng] Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang, 421000, China
[Jing Wang] Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha, 410219, China. 805598382@qq.com
[Jing Wang] Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research On Functional Nucleic Acid, Changsha Medical University, Changsha, 410219, China. 805598382@qq.com
[Jing Wang] The First Clinical College, Changsha Medical University, Changsha, 410219, China. 805598382@qq.com
通讯机构:
[Jing Wang] H
Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha, China<&wdkj&>Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research On Functional Nucleic Acid, Changsha Medical University, Changsha, China<&wdkj&>The First Clinical College, Changsha Medical University, Changsha, China
语种:
英文
关键词:
FHL2;Cardiac;Contractility;Fibrosis;Hypertrophy;LIM
期刊:
Molecular and Cellular Biochemistry
ISSN:
0300-8177
年:
2025
卷:
480
期:
4
页码:
2143-2157
基金类别:
This work was supported by the Natural Science Foundation of Hunan Province (No.2024JJ5325), the Excellent Youth Project of Hunan Provincial Education Department (No. 22B0411).
机构署名:
本校为第一机构
院系归属:
化学化工学院
医学院
摘要:
FHL2 (Four-and-a-half LIM domain protein 2) is a crucial factor involved in cardiac morphogenesis, the process by which the heart develops its complex structure. It is expressed in various tissues during embryonic development, including the developing heart, and has been shown to play important roles in cell proliferation, differentiation, and migration. FHL2 interacts with multiple proteins to regulate cardiac development as a coactivator or a corepressor. It is involved in cardiac specification and determination of cell fate, cardiomyocyte growth, cardiac remodeling, myofibrillogenesis, and ...

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