The application of main radionuclide in the department of nuclear medicine in a large-scale Hospital are introduced; Radiation levels of γ-rays and β-ray in all the workplace are monitored. It has been found that the highest γ-ray radiation level is in the Leaching-packing room, and the highest β-ray radiation level is in the temporary waste storage box. Possible impacts of main radionuclide on public and the staff are evaluated and according to the actual situation, the controlling measures of reducing the pollution are expounded, finally,...