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Death domain associated protein (Daxx), a multi-functional protein

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成果类型:
期刊论文
作者:
Tang, Shuang-Yang;Wan, Yan-Ping*;Wu, Yi-Mou
通讯作者:
Wan, Yan-Ping
作者机构:
[Tang, Shuang-Yang; Wan, Yan-Ping; Wu, Yi-Mou] Univ South China, Inst Pathogen Biol, Hengyang 421001, Peoples R China.
[Tang, Shuang-Yang; Wan, Yan-Ping; Wu, Yi-Mou] Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.
[Tang, Shuang-Yang; Wan, Yan-Ping; Wu, Yi-Mou] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
通讯机构:
[Wan, Yan-Ping] U
Univ South China, Inst Pathogen Biol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Death domain associated protein;Function;Mutation;Expression;Localization;Interaction;Modification;Regulation;Transcription;Apoptosis
期刊:
CELLULAR & MOLECULAR BIOLOGY LETTERS
ISSN:
1425-8153
年:
2015
卷:
20
期:
5
页码:
788-797
基金类别:
key discipline in Hunan province for Preclinical Medicine; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department) [2012-1, 2014-405]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control (Hunan Provincial Science and Technology Department document) [2014-5]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81402169]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell survival and apoptosis remain largely obscure. Our review of recent studies shows that Daxx has many interesting functional dualities and can...

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