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Co-delivery of antimicrobial peptide and Prussian blue nanoparticles by chitosan/polyvinyl alcohol hydrogels

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成果类型:
期刊论文
作者:
Liao, Zhiyi;Li, Jiayi;Ni, Wenqiang;Zhan, Rixing;Xu, Xisheng
通讯作者:
Xu, XS;Zhan, RX
作者机构:
[Ni, Wenqiang; Xu, Xisheng; Liao, Zhiyi; Li, Jiayi] Univ South China, Peoples Hosp Chenzhou 1, Dept Burn & Plast Surg, Chenzhou 423000, Peoples R China.
[Zhan, Rixing] Army Med Univ, Inst Burn Res, State Key Lab Trauma & Chem Poisoning, Southwest Hosp,Third Mil Med Univ, Chongqing 400038, Peoples R China.
通讯机构:
[Xu, XS ] U
[Zhan, RX ] A
Univ South China, Peoples Hosp Chenzhou 1, Dept Burn & Plast Surg, Chenzhou 423000, Peoples R China.
Army Med Univ, Inst Burn Res, State Key Lab Trauma & Chem Poisoning, Southwest Hosp,Third Mil Med Univ, Chongqing 400038, Peoples R China.
语种:
英文
关键词:
Antibacterial;Chitosan;Metal-organic framework;Photothermal hydrogel;Prussian blue;Wound healing
期刊:
Carbohydrate Polymers
ISSN:
0144-8617
年:
2025
卷:
348
期:
Pt A
页码:
122873
基金类别:
Chongqing Talent Plan [CQYC2021059323]; State Key Laboratory of Trauma and Chemical Poisoning Foundation of China [SKLYQ202202]; Chongqing Science and Health Joint Medical Research Key Project [2024ZDXM003]
机构署名:
本校为第一且通讯机构
摘要:
Altered skin integrity increases the chance of infection, and bacterial infections often lead to a persistent inflammatory response that prolongs healing time. Functional artificial hydrogels are receiving increasing attention as suitable wound dressing barrier. However, the antimicrobial effect of the new dressing still needs to be explored in depth. In this work, the antimicrobial peptide MSI-1 was covalently attached to chitosan-modified poly (vinyl alcohol) hydrogels mixed with Prussian blue nanoparticles (PBNPs) via a primary amine group c...

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