期刊论文

Tang, Yong-Bo

英文

Cardiovascular Drugs and Therapy

0920-3206

2012

26

1

31-40

10.1007/s10557-011-6351-3

Sources of Funding This work was supported by the National Natural Science Foundation of China (No.30900530), Science and Technology Planning Project of Guangdong Province, China (No.2008B030303061; No.2008B080703056; NO.2010B080701044; 2011B080701012), and Doctoral Fund of Ministry of Education of China (for young teachers, No.20090171120055).

本校为其他机构

Endothelial dysfunction contributes to the initiation and development of hypertension. We previously found that simvastatin moderately decreases blood pressure in 2-kidney-2-clip (2k2c) renal hypertension, but the precise mechanisms are still unclear. The present study was designed to examine the protective actions of simvastatin in 2k2c-evoked endothelial dysfunction and also delineate the underlying mechanisms. Here we show that 2k2c-induced elevation in plasma angiotensin II impaired acetylcholine-induced endothelium-dependent vascular relax...