AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE−/− mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Min;Zhao, Guo-Jun;Yao, Feng;Xia, Xiao-Dan;Gong, Duo;...

通讯作者：

Tang, Chao-Ke;Tang, Xiao-Er

作者机构：

[Gong, Duo; Tang, Chao-Ke; Zhao, Zhen-Wang; Yao, Feng; Chen, Ling-Yan; Xia, Xiao-Dan; Zhang, Min] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Zhao, Guo-Jun] Guilin Med Univ, Dept Histol & Embryol, 1 Zhiyuan Rd, Guilin 541100, Guangxi, Peoples R China.

[Tang, Xiao-Er] Shaoyang Univ, Dept Pathophysiol, Shaoyang 422000, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Tang, Chao-Ke] Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-Ke] U

[Tang, Xiao-Er] S

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

Shaoyang Univ, Dept Pathophysiol, Med Coll, Shaoyang 422000, Hunan, Peoples R China.

语种：

英文

关键词：

AIBP;Atherosclerosis;HDL;Inflammation;NF-kappaB;RCT

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2018

卷：

273

页码：

122-130

DOI：

10.1016/j.atherosclerosis.2018.03.010

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570408, 81370377, 81470569]; construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China) [[2011]76]; University of South China Innovation Foundation for Postgraduate [2016XCX04]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background and aims: ApoA-1 binding protein (AIBP) is a secreted protein that interacts with apoA-1 and accelerates cholesterol efflux from cells. We have recently reported that AIBP promotes apoA-1 binding to ABCA1 in the macrophage cell membrane, partially through 115-123 amino acids. However, the effects of AIBP on the development of atherosclerosis in vivo remain unknown. Methods: ApoE(-/-) mice with established atherosclerotic plaques were infected with rAAV-AIBP or rAAV-AIBP(Delta 115- 123), respectively. Results: AIBP-treated mice showed reduction of atherosclerotic lesion formation, in...

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AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE−/− mice

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