AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE−/− mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Min;Zhao, Guo-Jun;Yao, Feng;Xia, Xiao-Dan;Gong, Duo;...

通讯作者：

Tang, Chao-Ke;Tang, Xiao-Er

作者机构：

[Gong, Duo; Tang, Chao-Ke; Zhao, Zhen-Wang; Yao, Feng; Chen, Ling-Yan; Xia, Xiao-Dan; Zhang, Min] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Zhao, Guo-Jun] Guilin Med Univ, Dept Histol & Embryol, 1 Zhiyuan Rd, Guilin 541100, Guangxi, Peoples R China.

[Tang, Xiao-Er] Shaoyang Univ, Dept Pathophysiol, Shaoyang 422000, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Tang, Chao-Ke] Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-Ke] U

[Tang, Xiao-Er] S

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

Shaoyang Univ, Dept Pathophysiol, Med Coll, Shaoyang 422000, Hunan, Peoples R China.

语种：

英文

关键词：

ABC transporter A1;amino acid;apolipoprotein A1;apolipoprotein a1 binding protein;arg 1 protein;CXCL1 chemokine;CXCL2 chemokine;high density lipoprotein;immunoglobulin enhancer binding protein;intercellular adhesion molecule 1;monocyte chemotactic protein 1;mrc 1 protein;protein;unclassified drug;vascular cell adhesion molecule 1;apolipoprotein E;AUNIP protein, human;cholesterol;DNA binding protein;animal experiment;aorta;apolipoprotein E knockout mouse;Article;atherosclerosis;atherosclerotic plaque;cholesterol transport;controlled study;feces;human;in vivo study;inflammation;lipid storage;liver;macrophage;male;mouse;nonhuman;peritoneum macrophage;plasma;priority journal;animal;atherosclerosis;drug effect;genetics;inflammation;metabolism;physiology;transport at the cellular level;Animals;Apolipoproteins E;Atherosclerosis;Biological Transport;Cholesterol;DNA-Binding Proteins;Inflammation;Male;Mice

期刊：

Ateroskleroz

ISSN：

2078-256X

年：

2018

卷：

273

页码：

122-130

DOI：

10.1016/j.atherosclerosis.2018.03.010

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81570408, 81370377, and 81470569), the construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China, Xiangjiaofa NO. [2011]76), and University of South China Innovation Foundation for Postgraduate (2016XCX04). The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81570408 , 81370377 , and 81470569 ), the construct program of the key discipline in Hunan Province, China ( Basic Medicine Sciences in University of South China , Xiangjiaofa NO. [2011]76 ), and University of South China Innovation Foundation for Postgraduate ( 2016XCX04 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background and aims: ApoA-1 binding protein (AIBP) is a secreted protein that interacts with apoA-I and accelerates cholesterol efflux from cells. We have recently reported that AIBP promotes apoA-1 binding to ABCA1 in the macrophage cell membrane, partially through 115–123 amino acids. However, the effects of AIBP on the development of atherosclerosis in vivo remain unknown. Methods: ApoE−/− mice with established atherosclerotic plaques were infected with rAAV-AIBP or rAAV-AIBP(Δ115-123), respectively. Results: AIBP-treated mice showed red...

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AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE−/− mice

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