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MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I

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成果类型:
期刊论文
作者:
Ren, Kun;Zhu, Xiao;Zheng, Zhi;Mo, Zhong-Cheng;Peng, Xiao-Shan;...
通讯作者:
Yi, Guang-Hui
作者机构:
[Peng, Xiao-Shan; Ren, Kun; Zheng, Zhi; Zeng, Yong-Zhi; Yi, Guang-Hui; Zhu, Xiao; Qi, Hui-Zhou] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.
[Mo, Zhong-Cheng; Ou, Han-Xiao] Univ South China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.
[Zhang, Qing-Hai] Univ South China, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.
[Zhao, Guo-Jun] Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Guangxi, Peoples R China.
通讯机构:
[Yi, Guang-Hui] U
Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.
语种:
英文
关键词:
acyl coenzyme A desaturase;antagomir;apolipoprotein E;cholesterol;cholesterol acyltransferase;cholesterol ester;cholesterol ester transfer protein;cholesterol ester transfer protein h 3;fatty acid synthase;free cholesterol;glycerol 3 phosphate acyltransferase;high density lipoprotein cholesterol;hydroxymethylglutaryl coenzyme A reductase;insulin induced gene 1;iodine 125;microRNA 24;protein;radiopharmaceutical agent;scavenger receptor BI;small interfering RNA;sterol regulatory element binding protein 1c;sterol regulatory element binding protein 2;triacylglycerol;tritium;tyramine cellobiose i 125;unclassified drug;high density lipoprotein cholesterol;microRNA;MIRN24 microRNA, human;Mirn24 microRNA, mouse;SCARB1 protein, human;Scarb1 protein, mouse;scavenger receptor B;3' untranslated region;animal experiment;animal model;animal tissue;Article;atherogenesis;atherosclerosis;atherosclerotic plaque;binding site;cholesterol blood level;cholesterol level;controlled study;down regulation;enzyme chemistry;flow cytometry;gene overexpression;gene repression;genetic transfection;high performance liquid chromatography;human;human cell;in vitro study;in vivo study;lipid transport;liver cell;luciferase assay;macrophage;male;mouse;nonhuman;prediction;priority journal;promoter region;real time polymerase chain reaction;triacylglycerol blood level;Western blotting;animal;apolipoprotein E knockout mouse;atherosclerosis;blood;disease model;genetics;HEK293 cell line;Hep-G2 cell line;liver;metabolism;pathology;RNA processing;THP-1 cell line;3' Untranslated Regions;Animals;Atherosclerosis;Binding Sites;Cholesterol, HDL;Disease Models, Animal;HEK293 Cells;Hep G2 Cells;Humans;Liver;Macrophages;Male;Mice, Knockout, ApoE;MicroRNAs;RNA Processing, Post-Transcriptional;Scavenger Receptors, Class B;THP-1 Cells
期刊:
Ateroskleroz
ISSN:
2078-256X
年:
2018
卷:
270
页码:
57-67
基金类别:
The study was fiscally supported by the National Natural Sciences Foundation of China (No. 81770490 and 81670401 ), the Hunan Provincial Innovation Foundation For Postgraduates ( CX2017B503 ), the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions ( 2008-244 ) of Hunan Province, and the Construct Program of the Key Discipline in Hunan Province (Basic Medicine Sciences in University of South China) .
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Background and aims: Liver scavenger receptor class B type I (SR-BI) exerts atheroprotective effects through selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C). Low hepatic SR-BI expression leads to high HDL-C levels in the circulation and an increased risk of atherosclerosis. Furthermore, macrophage SR-BI mediates bidirectional cholesterol flux and may protect against atherogenesis. Previous studies have revealed that miR-24 is closely related to cardiovascular disease (CVD) progression. We aimed to investigate the ...

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