MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I

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成果类型：

期刊论文

作者：

Ren, Kun;Zhu, Xiao;Zheng, Zhi;Mo, Zhong-Cheng;Peng, Xiao-Shan;...

通讯作者：

Yi, Guang-Hui

作者机构：

[Peng, Xiao-Shan; Ren, Kun; Zheng, Zhi; Zeng, Yong-Zhi; Yi, Guang-Hui; Zhu, Xiao; Qi, Hui-Zhou] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

[Mo, Zhong-Cheng; Ou, Han-Xiao] Univ South China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Qing-Hai] Univ South China, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Zhao, Guo-Jun] Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Guangxi, Peoples R China.

通讯机构：

[Yi, Guang-Hui] U

Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Atherosclerosis;*HDL-Cholesterol;*SR-BI;*Selective lipid uptake;*miR-24

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2018

卷：

270

页码：

57-67

DOI：

10.1016/j.atherosclerosis.2018.01.045

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770490, 81670401]; Hunan Provincial Innovation Foundation For Postgraduates [CX2017B503]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]; Construct Program of the Key Discipline in Hunan Province (Basic Medicine Sciences in University of South China)

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background and aims: Liver scavenger receptor class B type I (SR-BI) exerts atheroprotective effects through selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C). Low hepatic SRBI expression leads to high HDL-C levels in the circulation and an increased risk of atherosclerosis. Furthermore, macrophage SR-BI mediates bidirectional cholesterol flux and may protect against atherogenesis. Previous studies have revealed that miR-24 is closely related to cardiovascular disease (CVD) progression. We aimed to investigate the molecular mechanisms by which miR-24 participates i...

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MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I

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