Dihydromyricetin alleviates hippocampal ferroptosis in type 2 diabetic cognitive impairment rats via inhibiting the JNK-inflammatory factor pathway

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成果类型：

期刊论文

作者：

Wang, Zihan;Feng, Shuidong;Li, Qi;Song, Zhenjiang;He, Jianqin;...

通讯作者：

Ling, HY;Yan, CQ

作者机构：

[Song, Zhenjiang; He, Jianqin; Li, Qi; Yang, Sisi; Ling, Hongyan; Wang, Zihan] Univ South China, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zihan] Chinese Univ Hong Kong, Sch Med, Shenzhen 518172, Guangdong, Peoples R China.

[Feng, Shuidong] Univ South China, Sch Publ Hlth, Dept Social Med & Hlth Serv Management, Hengyang 421001, Hunan, Peoples R China.

[Yan, Canqun] Univ South China, Affiliated Hosp 2, Hlth Management Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Ling, HY ; Yan, CQ ] U

Univ South China, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Hlth Management Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Cognitive impairment;Dihydromyricetin;Ferroptosis;JNK-inflammatory factor pathway;Type 2 diabetes mellitus

期刊：

Neuroscience Letters

ISSN：

0304-3940

年：

2023

卷：

812

页码：

137404

DOI：

10.1016/j.neulet.2023.137404

基金类别：

Natural Science Foundation of Hunan Province, China [2021JJ30595, 2021JJ50096]; health commission Foundation of Hunan Province, China [C202303076198]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Type 2 diabetes mellitus (T2DM) is frequently associated with diabetic cognitive impairment (DCI), and recent studies have shown a strong association between DCI and hippocampal ferroptosis. In this study, we administered dihydromyricetin (DHM) or JNK inhibitor SP600125, to T2DM rats and monitored changes in blood glucose levels, conducted behavioral tests, and detected changes in JNK, inflammatory factors and ferroptosis-related indicators. Our findings demonstrated that T2DM rats displayed signs of cognitive impairment (CI), with ferrozine as...

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Dihydromyricetin alleviates hippocampal ferroptosis in type 2 diabetic cognitive impairment rats via inhibiting the JNK-inflammatory factor pathway

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