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The role of caveolae in regulating calcitonin receptor-like receptor subcellular distribution in vascular smooth muscle cells.

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成果类型:
期刊论文
作者:
Tang, Jiang Qiong;Sun, Fei;Wang, Yu Hua;Chen, Lin Xi;Yao, Chao Hua;...
通讯作者:
Zhang, Liang
作者机构:
[Sun, Fei; Qin, Xu Ping; Tang, Jiang Qiong; Wang, Yu Hua; Chen, Lin Xi] Univ South China, Inst Pharm & Pharmacol, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.
[Zhang, Liang; Yao, Chao Hua] Palmer Coll Chiropract, Palmer Ctr Chiropract Res, Palmer Lab Cell & Mol Biol, Port Orange, FL 32129 USA.
[Fu, Xiao Qin] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Zhang, Liang] Palmer Coll Chiropract, Palmer Ctr Chiropract Res, Palmer Lab Cell & Mol Biol, 4705 S Clyde Morris Blvd, Port Orange, FL 32129 USA.
通讯机构:
[Zhang, Liang] P
Palmer Coll Chiropract, Palmer Ctr Chiropract Res, Palmer Lab Cell & Mol Biol, 4705 S Clyde Morris Blvd, Port Orange, FL 32129 USA.
语种:
英文
关键词:
calcitonin gene related peptide;calcitonin receptor-like receptor;caveolin-1;caveolae;vascular smooth muscle cells;peptide CGPR;récepteur CLR;cavéoline-1;cavéoles;cellules musculaires vasculaires lisses
期刊:
BIOCHEMISTRY AND CELL BIOLOGY
ISSN:
0829-8211
年:
2013
卷:
91
期:
5
页码:
357-360
基金类别:
National Nature Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [30572192, 81173060]; Palmer Chiropractic University Foundation
机构署名:
本校为第一机构
院系归属:
医学院
药学与生物科学学院
摘要:
To determine whether caveolae and caveolin-1 affect the distribution of calcitonin receptor-like receptors (CLR) in vascular smooth muscle cell (VSMC) membranes, we have used VSMCs cell line A10. We found that calcitonin gene-related peptide (CGRP) reduced CLR protein in the VSMC membrane in a time-dependent manner, which was dramatically decreased after 4 h CGRP treatment, and remained at a low level after 16 h. CGRP8-37 or β-cyclodextrin (β-CD) blocked this effect, without changing the total levels of CLR protein and mRNA in the cells. Co-i...

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