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Nanomessenger-Mediated Signaling Cascade for Antitumor Immunotherapy

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成果类型:
期刊论文
作者:
Zhao, Henan;Wang, Liqiang;Zeng, Ke;Li, Jianghua;Chen, Wansong;...
通讯作者:
Chen, Wansong(liuyounian@csu.edu.cn);Liu, You-Nian(chenws@csu.edu.cn)
作者机构:
[Chen, Wansong; Liu, You-Nian; Li, Jianghua; Zhao, Henan] Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China.
[Wang, Liqiang] Zhengzhou Univ, Sch Mat Sci & Engn, Henan Prov Ind Technol Res Inst Resources & Mat, Zhengzhou 450001, Henan, Peoples R China.
[Zeng, Ke] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构:
[Wansong Chen; You-Nian Liu] H
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, People’s Republic of China
语种:
英文
关键词:
chemical messenger;signal cascade;messenger amplifier;Ca2+-dependent cell death;antitumor immunotherapy
期刊:
ACS Nano
ISSN:
1936-0851
年:
2021
卷:
15
期:
8
页码:
13188-13199
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21807117, 21636010, 21878342, 52002054]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2020M673175]; Research Foundation of Education Bureau of Hunan Province [20C1636]
机构署名:
本校为其他机构
院系归属:
化学化工学院
摘要:
Chemical messengers have been recognized as signaling molecules involved in regulating various physiological and metabolic activities. Nevertheless, they usually show limited regulatory efficiency due to the complexity of biological processes. Especially for tumor cells, antideath pathways and tumor metastasis are readily activated to resist chemical messenger regulation, further impairing antitumor outcomes. Therefore, it is imperative to develop strategies for tumor eradication with chemical messengers. Herein, a nanomessenger was prepared wi...

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