VX-765 ameliorates CKD VSMC calcification by regulating STAT3 activation

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成果类型：

期刊论文

作者：

Duan, Yingjie;Peng, Zhong;Zhong, Shuzhu;Zhou, Peng;Huang, Hong;...

通讯作者：

He, Z.

作者机构：

[Duan, Yingjie; He, Zhangxiu; Zhong, Shuzhu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Nephrol, Hengyang 421001, Hunan, Peoples R China.

[Peng, Zhong; Zhou, Peng] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gastroenterol, Hengyang 421001, Hunan, Peoples R China.

[Huang, Hong] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Li, Jianlong] Southern Med Univ, Nanfang Hosp, Dept Orthoped Surg, Guangzhou, Guangdong, Peoples R China.

[Li, Jianlong] Weill Cornell Med, Dept Pediat, New York, NY USA.

通讯机构：

[He, Z.] T

The First Affiliated Hospital, 69 Chuanshan Road, Hunan Province, China

语种：

英文

关键词：

Calcification;Caspase-1;Pyroptosis;Vascular smooth muscle cells

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2023

卷：

945

页码：

175610

DOI：

10.1016/j.ejphar.2023.175610

基金类别：

This work was supported by the National Natural Science Foundation of China [grant numbers 81900678 , 81902730 ], the Natural Science Foundation of Hunan Province [grant number 2021JJ40491 ), Hunan Clinical Medical Technology Innovation and Guidance Project ( 2021SK51811 ), Scientific Research Project of Hunan Health Committee [grant numbers 202103051523 , B202303109098 ].

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

BACKGROUND: Recent clinical evidences show that caspase-1 inhibitor-VX-765 attenuates atherosclerosis in ApoE deficient mice. However, there is rarely information about the effect of VX-765 on hyperphosphatemia-induced vascular smooth muscle cells (VSMCs) calcification or vascular calcification in chronic kidney disease (CKD) rats. Here we investigate the effect of VX-765 on vascular calcification in uremia circumstances. METHODS: Hyperphosphatemia-induced VSMC calcification were evaluated by Alizarin Red S. Aortas from CKD rats which were gava...

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VX-765 ameliorates CKD VSMC calcification by regulating STAT3 activation

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