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The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway

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成果类型:
期刊论文
作者:
Ouyang, Bo;Li, Zili;Ji, Xiongying;Huang, Jiangwei;Zhang, Hengsheng;...
通讯作者:
Jiang, Changrong
作者机构:
[Zhang, Hengsheng; Ouyang, Bo] Univ South China, Affiliated Nanhua Hosp, Dept Tradit Chinese Med Rehabil, Hengyang, Peoples R China.
[Li, Zili; Jiang, Changrong; Huang, Jiangwei] Univ South China, Affiliated Nanhua Hosp, Dept Cardiol, Hengyang 421002, Hunan, Peoples R China.
[Ji, Xiongying] Univ South China, Affiliated Nanhua Hosp, Dept Gastroenterol, Hengyang, Peoples R China.
通讯机构:
[Jiang, Changrong] U
Univ South China, Affiliated Nanhua Hosp, Dept Cardiol, Hengyang 421002, Hunan, Peoples R China.
语种:
英文
关键词:
Myocardial infarction;cardiac markers;cardioprotective;infarct size
期刊:
Pharmaceutical Biology
ISSN:
1388-0209
年:
2019
卷:
57
期:
1
页码:
529-535
基金类别:
University of South China [USC-CS-134/24354]
机构署名:
本校为第一且通讯机构
摘要:
Context: Lutein (LU) is a major carotenoid with various pharmacological activities including anti-inflammatory, antioxidant and anti-apoptosis. Objective: The cardioprotective efficacy of LU was determined by evaluating the biochemical and histopathological changes in isoproterenol (ISO) induced myocardial infarction (MI) rat model. Materials and methods: Healthy male albino rats (n = 40) were segregated into 4 equal groups. Group I (control) rats were administered with olive oil, Group II (LU) rats were orally pre-treated with only 40 mg of LU for 28 days, Group III (MI induced) rats were inj...

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